CD36

CD36 — мембранный белок, экспрессированный на поверхности клеток нескольких типов, особенно макрофагах; относится к классу B скэвенджер-рецепторов, компонент системы врождённого иммунитета. Связывает эритроциты, заражённые паразитическим Plasmodium falciparum, окисленные липопротеины низкой плотности, фосфолипиды и жирные кислоты. Кроме этого, CD36, экспрессированный на поверхности эпителия вкусовых сосочков языка, является рецептором, связывающим жирные кислоты пищи и участвующим в формировании «вкуса жира».

CD36
Идентификаторы
Символ	CD36 ; BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
Внешние ID	OMIM: 173510 MGI: 107899 HomoloGene: 73871 ChEMBL: 1744526 GeneCards: CD36 Gene
Генная онтология Функция • low-density lipoprotein receptor activity • high-density lipoprotein particle binding • lipid binding • low-density lipoprotein particle binding • transforming growth factor beta binding • thrombospondin receptor activity • lipoteichoic acid receptor activity • lipoprotein particle binding Компонент клетки • extracellular space • Golgi apparatus • plasma membrane • integral component of plasma membrane • external side of plasma membrane • cell surface • membrane • endocytic vesicle membrane • platelet alpha granule membrane • membrane raft • phagocytic vesicle Биологический процесс • negative regulation of transcription from RNA polymerase II promoter • positive regulation of cell-matrix adhesion • toll-like receptor signaling pathway • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • platelet degranulation • MyD88-dependent toll-like receptor signaling pathway • lipid metabolic process • receptor-mediated endocytosis • phagocytosis, recognition • cell adhesion • cell surface receptor signaling pathway • nitric oxide mediated signal transduction • blood coagulation • positive regulation of macrophage derived foam cell differentiation • positive regulation of cholesterol storage • plasma membrane long-chain fatty acid transport • lipid storage • cGMP-mediated signaling • platelet activation • positive regulation of blood coagulation • cholesterol transport • positive regulation of interleukin-12 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • toll-like receptor 2 signaling pathway • toll-like receptor 4 signaling pathway • plasma lipoprotein particle clearance • low-density lipoprotein particle clearance • response to stilbenoid • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • antigen processing and presentation of exogenous peptide antigen via MHC class I • lipoprotein transport • negative regulation of transcription factor import into nucleus • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic cell clearance • positive regulation of MAPK cascade • negative regulation of growth of symbiont in host • cellular lipid metabolic process • small molecule metabolic process • long-chain fatty acid import • innate immune response • positive regulation of peptidyl-tyrosine phosphorylation • defense response to Gram-positive bacterium • low-density lipoprotein particle mediated signaling • positive regulation of phagocytosis, engulfment • positive regulation of macrophage cytokine production • cellular response to bacterial lipopeptide • cellular response to lipopolysaccharide • cellular response to lipoteichoic acid • cellular response to hydroperoxide • regulation of removal of superoxide radicals • positive regulation of blood microparticle formation • positive regulation of reactive oxygen species metabolic process Источники: Amigo / QuickGO
Профиль экспрессии РНК
Больше информации
Ортологи
Вид	Человек	Мышь
Entrez	948	12491
Ensembl	ENSG00000135218	ENSMUSG00000002944
UniProt	P16671	Q08857
RefSeq (мРНК)	NM_000072	NM_001159555
RefSeq (белок)	NP_000063	NP_001153027
Локус (UCSC)	Chr 7: 80 – 80.31 Mb	Chr 5: 17.78 – 17.89 Mb
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