Толл-подобный рецептор 2

Толл-подобный рецептор 2
Толл-подобный рецептор 2
	; 1FYW
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1FYW, 1FYX, 1O77, 2Z7X, 2Z80
Идентификаторы
Символ	TLR2 ; CD282; TIL4
Внешние ID	OMIM: 603028 MGI: 1346060 HomoloGene: 20695 ChEMBL: 4163 GeneCards: TLR2 Gene
Генная онтология
Генная онтология
Функция	• lipopolysaccharide receptor activity; • receptor activity; • transmembrane signaling receptor activity; • protein binding; • signaling pattern recognition receptor activity; • triacyl lipopeptide binding; • diacyl lipopeptide binding; • peptidoglycan binding; • protein heterodimerization activity; • lipoteichoic acid binding;
Компонент клетки	• cytoplasm; • plasma membrane; • integral component of plasma membrane; • external side of plasma membrane; • cell surface; • Toll-like receptor 1-Toll-like receptor 2 protein complex; • Toll-like receptor 2-Toll-like receptor 6 protein complex; • cell projection; • cell body;
Биологический процесс	• response to hypoxia; • toll-like receptor signaling pathway; • response to molecule of fungal origin; • microglial cell activation involved in immune response; • positive regulation of leukocyte migration; • cell surface pattern recognition receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • leukotriene metabolic process; • apoptotic process; • inflammatory response; • immune response; • signal transduction; • I-kappaB phosphorylation; • negative regulation of cell proliferation; • response to toxic substance; • positive regulation of Wnt signaling pathway; • lipopolysaccharide-mediated signaling pathway; • central nervous system myelin formation; • response to progesterone; • negative regulation of interleukin-12 production; • negative regulation of interleukin-17 production; • positive regulation of chemokine production; • positive regulation of interferon-beta production; • positive regulation of interleukin-10 production; • positive regulation of interleukin-12 production; • positive regulation of interleukin-18 production; • positive regulation of interleukin-6 production; • positive regulation of interleukin-8 production; • positive regulation of tumor necrosis factor production; • response to insulin; • positive regulation of toll-like receptor signaling pathway; • toll-like receptor 2 signaling pathway; • toll-like receptor 4 signaling pathway; • toll-like receptor TLR1:TLR2 signaling pathway; • toll-like receptor TLR6:TLR2 signaling pathway; • positive regulation of NF-kappaB import into nucleus; • detection of triacyl bacterial lipopeptide; • detection of diacyl bacterial lipopeptide; • positive regulation of tumor necrosis factor biosynthetic process; • chloramphenicol transport; • negative regulation of growth of symbiont in host; • innate immune response; • positive regulation of nitric oxide biosynthetic process; • positive regulation of transcription from RNA polymerase II promoter; • nitric oxide metabolic process; • positive regulation of oligodendrocyte differentiation; • positive regulation of cytokine secretion; • positive regulation of inflammatory response; • defense response to Gram-positive bacterium; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of nitric-oxide synthase biosynthetic process; • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; • induction by symbiont of defense-related host nitric oxide production; • positive regulation of macrophage cytokine production; • response to fatty acid; • cellular response to bacterial lipopeptide; • cellular response to lipoteichoic acid; • cellular response to peptidoglycan; • cellular response to diacyl bacterial lipopeptide; • cellular response to triacyl bacterial lipopeptide;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
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Ортологи

TLR2 (толл-подобный рецептор 2, CD282) — мембранный белок, входящий в группу толл-подобных рецепторов, обеспечивающих функционирование врождённого иммунитета. TLR2 так же как TLR1 распознаёт патоген-связанные молекулярные структуры грам-положительных бактерий, включая пептидогликаны, липотейхоевую кислоту, некоторые компоненты микобактерий и зимозан клеточной стенки дрожжей.

Библиография

Tapping R.I., Omueti K.O., Johnson C.M. Genetic polymorphisms within the human Toll-like receptor 2 subfamily (англ.) // Biochem. Soc. Trans. : journal. — 2007. — December (vol. 35, no. Pt 6). — P. 1445—1448. — doi:10.1042/BST0351445. — PMID 18031242.

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Белки: Кластеры дифференцировки
1-50	CD1 (a-c, 1A, 1D, 1E) CD2 CD3 (γ, δ, ε) CD4 CD5 CD6 CD7 CD8 (a) CD9 CD10 CD11 (a, b, c, d) CD13 CD14 CD15 CD16 (A, B) CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 (A, B) CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 (a, b, c, d) CD43 CD44 CD45 CD46 CD47 CD48 CD49 (a, b, c, d, e, f) CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 (E, L, P) CD63 CD64 (A, B, C) CD66 (a, b, c, d, e, f) CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 (a, b) CD80 CD81 CD82 CD83 CD84 CD85 (a, d, e, h, j, k) CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 (a, b) CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 (a, b) CD121 (a, b) CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 (a, b, c) CD157 CD158 (a, d, e, i, k) CD159 (a, c) CD160 CD161 CD162 CD163 CD164 CD166 CD167 (a, b) CD168 CD169 CD170 CD171 CD172 (a, b, g) CD174 CD177 CD178 CD179 (a, b) CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 (a, b) CD212 CD213a (1, 2) CD217 CD218 (a, b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 (a, b) CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD270 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD319 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351-400	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371