Нейропилин 1

Нейропилин 1
Нейропилин 1
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G
Идентификаторы
Символы	NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Neuropilin 1
Внешние IDs	OMIM: 602069 MGI: 106206 HomoloGene: 2876 GeneCards: 8829
Связанные наследственные заболевания
Название болезнии	Ссылки
Генная онтология
Генная онтология
Функции	• heparin binding; • vascular endothelial growth factor binding; • cytokine binding; • semaphorin receptor activity; • coreceptor activity; • связывание с ионом металла; • vascular endothelial growth factor-activated receptor activity; • growth factor binding; • GO:0001948 связывание с белками плазмы; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • protein kinase binding;
Компонент клетки	• цитозоль; • мембрана; • внеклеточная область; • semaphorin receptor complex; • поверхность клетки; • sorting endosome; • часть мембраны; • Конус роста; • receptor complex; • клеточная мембрана; • аксон; • neuronal cell body; • early endosome; • нейрофиламент; • GO:0016023 cytoplasmic vesicle; • внеклеточное пространство; • Фокальные контакты; • neuron projection; • glutamatergic synapse; • integral component of postsynaptic membrane;
Биологический процесс	• negative regulation of neuron apoptotic process; • facioacoustic ganglion development; • vascular endothelial growth factor signaling pathway; • VEGF-activated neuropilin signaling pathway involved in axon guidance; • toxin transport; • cell migration involved in sprouting angiogenesis; • semaphorin-plexin signaling pathway involved in axon guidance; • positive regulation of retinal ganglion cell axon guidance; • positive regulation of smooth muscle cell migration; • sympathetic neuron projection guidance; • vascular endothelial growth factor receptor signaling pathway; • sensory neuron axon guidance; • Ангиогенез; • positive regulation of ERK1 and ERK2 cascade; • морфогенез органа животных; • protein localization to early endosome; • trigeminal nerve structural organization; • regulation of axon extension involved in axon guidance; • coronary artery morphogenesis; • negative regulation of extrinsic apoptotic signaling pathway; • neuron development; • trigeminal nerve morphogenesis; • angiogenesis involved in coronary vascular morphogenesis; • commissural neuron axon guidance; • negative regulation of axon extension involved in axon guidance; • развитие сердца; • response to wounding; • artery morphogenesis; • positive regulation of peptidyl-tyrosine phosphorylation; • branching involved in blood vessel morphogenesis; • platelet-derived growth factor receptor signaling pathway; • positive chemotaxis; • facial nerve structural organization; • hepatocyte growth factor receptor signaling pathway; • axonal fasciculation; • retina vasculature morphogenesis in camera-type eye; • dorsal root ganglion morphogenesis; • axon extension involved in axon guidance; • sympathetic ganglion development; • Дифференцировка клеток; • semaphorin-plexin signaling pathway involved in neuron projection guidance; • cellular response to hepatocyte growth factor stimulus; • dendrite development; • sprouting angiogenesis; • neuron migration; • nervous system development; • regulation of retinal ganglion cell axon guidance; • branchiomotor neuron axon guidance; • gonadotrophin-releasing hormone neuronal migration to the hypothalamus; • negative regulation of axon extension; • retinal ganglion cell axon guidance; • renal artery morphogenesis; • ventral trunk neural crest cell migration; • positive regulation of endothelial cell proliferation; • sympathetic nervous system development; • endothelial tip cell fate specification; • передача сигнала между клетками; • regulation of vesicle-mediated transport; • trigeminal ganglion development; • positive regulation of cytokine activity; • positive regulation of axon extension involved in axon guidance; • Аксональное наведение; • vestibulocochlear nerve structural organization; • multicellular organism development; • neural crest cell migration involved in autonomic nervous system development; • endothelial cell chemotaxis; • axonogenesis involved in innervation; • dichotomous subdivision of terminal units involved in salivary gland branching; • cellular response to vascular endothelial growth factor stimulus; • motor neuron axon guidance; • nerve development; • миграция клеток; • sympathetic neuron projection extension; • semaphorin-plexin signaling pathway; • передача сигнала; • otic placode development; • motor neuron migration; • outflow tract septum morphogenesis; • substrate-dependent cell migration, cell extension; • integrin-mediated signaling pathway; • positive regulation of endothelial cell migration; • actin cytoskeleton reorganization; • regulation of Cdc42 protein signal transduction; • substrate adhesion-dependent cell spreading; • neuropilin signaling pathway; • VEGF-activated neuropilin signaling pathway; • positive regulation of phosphorylation; • endothelial cell migration; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • positive regulation of angiogenesis; • positive regulation of filopodium assembly; • positive regulation of stress fiber assembly; • positive regulation of focal adhesion assembly; • positive regulation of cell migration involved in sprouting angiogenesis; • positive regulation of substrate adhesion-dependent cell spreading; • positive regulation of actin cytoskeleton reorganization; • postsynapse organization; • basal dendrite development; • basal dendrite arborization;
	Источники:Amigo / QuickGO
Профиль экспрессии РНК
	; ; ; ;
	Больше информации
Ортологи
	8829
	18186
	ENSG00000099250
	ENSMUSG00000025810
	O14786
	P97333
NM_001024628; NM_001024629; NM_001244972; NM_001244973; NM_003873;
	NM_001330068
	NM_008737; NM_001358959; NM_001358960
NP_001019799; NP_001019800; NP_001231901; NP_001231902; NP_001316997;
	NP_003864
	NP_032763; NP_001345888; NP_001345889
Править (человек)	Править (мышь)

Нейропилин 1 (англ. Neuropilin 1, NRP1; CD304) — мембранный белок, экспрессирован в нейронах, продукт гена NRP1.[1][2][3] Один из двух нейропилинов человека.

Функции

Нейропилин 1 является мембрано-связанным ко-рецептором тирозинкиназного рецептора факторов роста эндотелия сосудов (VEGF) и семафоринов. Играет роль в VEGF-индуцированном ангиогенезе, направлении роста аксона, выживании, миграции и прорастании клеток[3].

Взаимодействия

Нейропилин 1 связывается с VEGF-A, VEGF-B[1][4], семафорином 3A.

См. также

Нейропилин 2

Примечания

Soker S., Takashima S., Miao H.Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor (англ.) // Cell : journal. — Cell Press, 1998. — March (vol. 92, no. 6). — P. 735—745. — doi:10.1016/S0092-8674(00)81402-6. — PMID 9529250.
Chen H., Chédotal A., He Z., Goodman C.S., Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III (англ.) // Neuron : journal. — Cell Press, 1997. — September (vol. 19, no. 3). — P. 547—559. — doi:10.1016/S0896-6273(00)80371-2. — PMID 9331348.
Entrez Gene: NRP1 neuropilin 1 (неопр.).
Mamluk R., Gechtman Z., Kutcher M.E., Gasiunas N., Gallagher J., Klagsbrun M. Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain (англ.) // The Journal of Biological Chemistry : journal. — 2002. — July (vol. 277, no. 27). — P. 24818—24825. — doi:10.1074/jbc.M200730200. — PMID 11986311.

Литература

Zachary I., Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family (англ.) // Cardiovascular Research : journal. — 2001. — February (vol. 49, no. 3). — P. 568—581. — doi:10.1016/S0008-6363(00)00268-6. — PMID 11166270.
He Z., Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III (англ.) // Cell : journal. — Cell Press, 1997. — August (vol. 90, no. 4). — P. 739—751. — doi:10.1016/S0092-8674(00)80534-6. — PMID 9288753.
Giger R.J., Urquhart E.R., Gillespie S.K., Levengood D.V., Ginty D.D., Kolodkin A.L. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity (англ.) // Neuron : journal. — Cell Press, 1998. — November (vol. 21, no. 5). — P. 1079—1092. — doi:10.1016/S0896-6273(00)80625-X. — PMID 9856463.
Chen H., He Z., Bagri A., Tessier-Lavigne M. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins (англ.) // Neuron : journal. — Cell Press, 1998. — December (vol. 21, no. 6). — P. 1283—1290. — doi:10.1016/S0896-6273(00)80648-0. — PMID 9883722.
Takahashi T., Nakamura F., Jin Z., Kalb R.G., Strittmatter S.M. Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors (англ.) // Nature Neuroscience : journal. — 1998. — October (vol. 1, no. 6). — P. 487—493. — doi:10.1038/2203. — PMID 10196546.
Rossignol M., Beggs A.H., Pierce E.A., Klagsbrun M. Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively (англ.) // Genomics : journal. — Academic Press, 1999. — May (vol. 57, no. 3). — P. 459—460. — doi:10.1006/geno.1999.5790. — PMID 10329017.
Makinen T., Olofsson B., Karpanen T., Hellman U., Soker S., Klagsbrun M., Eriksson U., Alitalo K. Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1 (англ.) // The Journal of Biological Chemistry : journal. — 1999. — July (vol. 274, no. 30). — P. 21217—21222. — doi:10.1074/jbc.274.30.21217. — PMID 10409677.
Cai H., Reed R.R. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1 (англ.) // The Journal of Neuroscience : journal. — 1999. — August (vol. 19, no. 15). — P. 6519—6527. — PMID 10414980.
Takahashi T., Fournier A., Nakamura F., Wang L.H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors (англ.) // Cell. — Cell Press, 1999. — October (vol. 99, no. 1). — P. 59—69. — doi:10.1016/S0092-8674(00)80062-8. — PMID 10520994.
Tamagnone L., Artigiani S., Chen H., He Z., Ming G.I., Song H., Chedotal A., Winberg M.L., Goodman C.S., Poo M., Tessier-Lavigne M., Comoglio P.M. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates (англ.) // Cell : journal. — Cell Press, 1999. — October (vol. 99, no. 1). — P. 71—80. — doi:10.1016/S0092-8674(00)80063-X. — PMID 10520995.
Gagnon M.L., Bielenberg D.R., Gechtman Z., Miao H.Q., Takashima S., Soker S., Klagsbrun M. Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — March (vol. 97, no. 6). — P. 2573—2578. — doi:10.1073/pnas.040337597. — PMID 10688880.
Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected] (англ.) // The Journal of Biological Chemistry : journal. — 2000. — June (vol. 275, no. 24). — P. 18040—18045. — doi:10.1074/jbc.M909259199. — PMID 10748121.
Fuh G., Garcia K.C., de Vos A.M. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1 (англ.) // The Journal of Biological Chemistry : journal. — 2000. — September (vol. 275, no. 35). — P. 26690—26695. — doi:10.1074/jbc.M003955200. — PMID 10842181.
Rossignol M., Gagnon M.L., Klagsbrun M. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms (англ.) // Genomics : journal. — Academic Press, 2000. — December (vol. 70, no. 2). — P. 211—222. — doi:10.1006/geno.2000.6381. — PMID 11112349.
Simpson J.C., Wellenreuther R., Poustka A., Pepperkok R., Wiemann S. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing (англ.) // EMBO Reports : journal. — 2000. — September (vol. 1, no. 3). — P. 287—292. — doi:10.1093/embo-reports/kvd058. — PMID 11256614.
Whitaker G.B., Limberg B.J., Rosenbaum J.S. Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121) (англ.) // The Journal of Biological Chemistry : journal. — 2001. — July (vol. 276, no. 27). — P. 25520—25531. — doi:10.1074/jbc.M102315200. — PMID 11333271.
Walter J.W., North P.E., Waner M., Mizeracki A., Blei F., Walker J.W., Reinisch J.F., Marchuk D.A. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma (англ.) // Genes, Chromosomes & Cancer : journal. — 2002. — March (vol. 33, no. 3). — P. 295—303. — doi:10.1002/gcc.10028. — PMID 11807987.

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[pmid9529250-1] Soker S., Takashima S., Miao H.Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor (англ.) // Cell : journal. — Cell Press, 1998. — March (vol. 92, no. 6). — P. 735—745. — doi:10.1016/S0092-8674(00)81402-6. — PMID 9529250.

[pmid9331348-2] Chen H., Chédotal A., He Z., Goodman C.S., Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III (англ.) // Neuron : journal. — Cell Press, 1997. — September (vol. 19, no. 3). — P. 547—559. — doi:10.1016/S0896-6273(00)80371-2. — PMID 9331348.

[entrez-3] Entrez Gene: NRP1 neuropilin 1 (неопр.).

[pmid11986311-4] Mamluk R., Gechtman Z., Kutcher M.E., Gasiunas N., Gallagher J., Klagsbrun M. Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain (англ.) // The Journal of Biological Chemistry : journal. — 2002. — July (vol. 277, no. 27). — P. 24818—24825. — doi:10.1074/jbc.M200730200. — PMID 11986311.

Белки: Кластеры дифференцировки
1-50	CD1 (a-c, 1A, 1D, 1E) CD2 CD3 (γ, δ, ε) CD4 CD5 CD6 CD7 CD8 (a) CD9 CD10 CD11 (a, b, c, d) CD13 CD14 CD15 CD16 (A, B) CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 (A, B) CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 (a, b, c, d) CD43 CD44 CD45 CD46 CD47 CD48 CD49 (a, b, c, d, e, f) CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 (E, L, P) CD63 CD64 (A, B, C) CD66 (a, b, c, d, e, f) CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 (a, b) CD80 CD81 CD82 CD83 CD84 CD85 (a, d, e, h, j, k) CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 (a, b) CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 (a, b) CD121 (a, b) CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 (a, b, c) CD157 CD158 (a, d, e, i, k) CD159 (a, c) CD160 CD161 CD162 CD163 CD164 CD166 CD167 (a, b) CD168 CD169 CD170 CD171 CD172 (a, b, g) CD174 CD177 CD178 CD179 (a, b) CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 (a, b) CD212 CD213a (1, 2) CD217 CD218 (a, b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 (a, b) CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD270 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD319 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351-400	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371