Гистондеацетилаза 1

Гистондеацетилаза 1
Гистондеацетилаза 1
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1TYI, 4BKX
Идентификаторы
Символ	HDAC1 ; GON-10; HD1; RPD3; RPD3L1
Внешние ID	OMIM: 601241 MGI: 108086 HomoloGene: 68426 ChEMBL: 325 GeneCards: HDAC1 Gene
номер EC	3.5.1.98
Генная онтология
Генная онтология
Функция	• transcription regulatory region sequence-specific DNA binding; • RNA polymerase II core promoter proximal region sequence-specific DNA binding; • RNA polymerase II distal enhancer sequence-specific DNA binding; • core promoter binding; • RNA polymerase II repressing transcription factor binding; • RNA polymerase II transcription corepressor activity; • sequence-specific DNA binding transcription factor activity; • histone deacetylase activity; • protein binding; • transcription factor binding; • deacetylase activity; • enzyme binding; • nucleosomal DNA binding; • NAD-dependent histone deacetylase activity (H3-K14 specific); • protein deacetylase activity; • activating transcription factor binding; • histone deacetylase binding; • NAD-dependent histone deacetylase activity (H3-K9 specific); • NAD-dependent histone deacetylase activity (H4-K16 specific); • NAD-dependent histone deacetylase activity (H3-K18 specific);
Компонент клетки	• histone deacetylase complex; • nuclear chromatin; • nucleus; • nucleoplasm; • nucleolus; • cytoplasm; • cytosol; • Sin3 complex; • NuRD complex; • protein complex;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • mitotic cell cycle; • chromatin remodeling; • transcription, DNA-templated; • transcription initiation from RNA polymerase II promoter; • protein deacetylation; • transforming growth factor beta receptor signaling pathway; • Notch signaling pathway; • blood coagulation; • positive regulation of cell proliferation; • epidermal cell differentiation; • gene expression; • negative regulation of myotube differentiation; • positive regulation of receptor biosynthetic process; • viral process; • chromatin modification; • histone deacetylation; • circadian regulation of gene expression; • odontogenesis of dentin-containing tooth; • embryonic digit morphogenesis; • ATP-dependent chromatin remodeling; • negative regulation of apoptotic process; • negative regulation by host of viral transcription; • negative regulation of cell cycle; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • neurotrophin TRK receptor signaling pathway; • negative regulation of androgen receptor signaling pathway; • hair follicle placode formation; • eyelid development in camera-type eye; • fungiform papilla formation; • histone H3 deacetylation; • histone H4 deacetylation;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

Гистондеацетилаза 1 — фермент, который у человека кодируется геном HDAC1 .[1]

Функция

Осуществляет ацетилирование и деацетилирование гистонов, катализ мультисубъединичных комплексов, играет ключевую роль в регуляции в экспрессии эукариотических генов. Белок, кодируемый этим геном относится к семейству гистондезацетилаза/acuc/apha и является составной частью гистондезацетилазного комплекса. Он также взаимодействует с белком-супрессором опухоли ретинобластомы, и этот комплекс является ключевым элементом в управлении клеточной пролиферацией и дифференцировкой. Вместе с метастазосвязанным белком-2 MTA2, деацетилирует p53 и модулирует его действие на рост клеток и апоптоз.[2]

Модельные организмы

*Hdac1* фенотипа нокаутная мышь
Характеристики	Фенотип
Жизнеспособность гомозитов	Ненормальный
Recessive lethal study	ненормальный
Плодовитость	Норма
Вес тела	Норма
Тревога	Норма
Неврологическое обследование	Норма
Сила хватания	Норма
Hot plate	Норма
Dysmorphology	Норма
Indirect calorimetry	Норма
Глюкозотолерантный тест	Норма
Auditory brainstem response	Норма
DEXA	Норма
Рентгенография	Норма
Температура тела	Норма
Eye morphology	Норма
Клиническая химия	Норма
Гематология	Норма
Лимфоциты периферийной крови	Норма
Тест микроядер	Норма
Масса сердца	Норма
Гистопатология мозга	Норма
Гистопатология глаз	Норма
Сальмонелла	Normal[3]
Citrobacter infection	Normal[4]
Все тесты и анализы из[5][6]

Модельные организмы были использованы при исследовании функции HDAC1. Условная линия нокаутных мышей, под названием Hdac1^{tm1a(EUCOMM)Wtsi}[7][8] была создана в рамках международной программы консорциума Нокаутная мышь — проект мутагенеза высокой пропускной способности для создания и распространения животных моделей для изучения болезней заинтересованными учеными — в институте Сенгера.[9][10][11] Мужские и женские особи прошли стандартное фенотипическое обследование для определения последствий удаления.[5][12] Двадцать пять испытаний были проведены и два фенотипа оказались с отклонениями. Сокращение числа гомозиготных мутантов были определены у эмбрионов во время беременности, и никто не дожил до конца лактации. Остальные испытания проводились на гетерозиготных мутантах взрослых мышей, и не было обнаружено каких-либо существенных отклонений у этих животных.[5]

Взаимодействия

HDAC 1,как было выявлено, взаимодействует с:

Андрогенный рецептор,[13]
BCL6,[14][15]
BTG2,[16]
BUB1B,[17]
BUB1,[17]
BUB3,[17]
CBFA2T3,[18][19]
CDC20,[17]
CDH1,[17]
CHD3,[20][21]
CHD4,[22][20][23]
COUP-TFII,[24]
CTBP1,[25][26][27]
DDX17,[28]
DDX5,[28]
DNMT3A,[29]
DNMT3L,[30][31]
Death-associated protein 6,[32]
EED,[33]
EVI1,[34][35]
EZH2,[33]
FKBP3,[36]
GATA1,[37]
HMG20B,[38]
HSPA4,[39]
HUS1,[40]
Гистондеацетилаза 2,[22][41][38][42][43][39][44][45][46][20][47][48][33]
TGIF1,[25][49]
HCFC1,[50]
IFRD1,[51]
IKZF1,[52][53]
ING1,[21][54]
MBD3,[46][55][56]
MIER1,[57]
MLL,[58]
MTA1,[22][59]
MTA2,[22][46][60][61]
Mad1,[17]
Mdm2,[62]
MBD2,[46][63][64]
SMAD2,[65]
MyoD,[66][67]
NFKB1,[68]
NCOR2,[41][69]
PCNA,[70]
PHF21A,[38][71]
Прохибитин,[72][73]
Белок промиелоцитарного лейкоза,[74][75]
RAD9A,[40]
RBBP4,[22][46][47][48][76][23][60][77][63][78][79]
RBBP7,[22][46][48][63]
RCOR1,[38][60]
RELA,[45][80][68]
RFC1,[81]
Белок ретинобластомы,[73][66][82][83][84][85][86]
RBL1,[82][83]
RBL2,[82][87]
SAP30,[46][21][88][89][90][91]
SATB1,[61]
SIN3A,[22][46][20][47][76][92][93][23][94][60][77][61][95][21]
SIN3B,[52][46]
SPEN,[96]
SUDS3,[92][97]
SUV39H1,[98]
Sp1,[77][99][100][101]
TOP2A,[102][103]
TOP2B,[102][103] and
Цинковый палец и BTB домен, содержащий белок 16.[104][14][105]

Примечания

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[allele_ref-7] International Knockout Mouse Consortium (неопр.) (недоступная ссылка). Дата обращения: 2 апреля 2015. Архивировано 20 марта 2012 года.

[mgi_allele_ref-8] Mouse Genome Informatics (неопр.).

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