SIN3A

Член A семейства регуляторов транскрипции SIN3
Член A семейства регуляторов транскрипции SIN3
	; PDB представлено на основе 1g1e.
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1PO4
Идентификаторы
Символ	SIN3A ; DKFZp434K2235; FLJ90319; KIAA0700
Внешние ID	OMIM: 607776 MGI: 107157 HomoloGene: 32124 GeneCards: SIN3A Gene
Генная онтология
Генная онтология
Функция	• transcription regulatory region sequence-specific DNA binding; • RNA polymerase II activating transcription factor binding; • RNA polymerase II repressing transcription factor binding; • RNA polymerase II transcription corepressor activity; • chromatin binding; • sequence-specific DNA binding transcription factor activity; • transcription corepressor activity; • protein binding; • protein complex binding; • protein deacetylase activity;
Компонент клетки	• kinetochore; • nucleus; • nucleoplasm; • transcription factor complex; • nucleolus; • cytoplasm; • Sin3 complex; • transcriptional repressor complex; • intercellular bridge;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • in utero embryonic development; • activation of innate immune response; • positive regulation of defense response to virus by host; • DNA replication; • transcription, DNA-templated; • protein deacetylation; • aging; • blood coagulation; • response to organonitrogen compound; • positive regulation of G2/M transition of mitotic cell cycle; • positive regulation of chromatin silencing; • cellular protein localization; • negative regulation of circadian rhythm; • negative regulation of apoptotic process; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • cellular lipid metabolic process; • small molecule metabolic process; • negative regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • rhythmic process; • response to methylglyoxal; • cellular response to glucose stimulus; • negative regulation of protein localization to nucleus; • negative regulation of histone H3-K27 acetylation; • negative regulation of transcription regulatory region DNA binding;
	Источники: Amigo / QuickGO
Ортологи

SIN3A (англ. Paired amphipathic helix protein Sin3a — белок парной амфипатической спирали Sin3a) — белок, кодируемый у человека геном SIN3A[1][2].

Функция

Белок, кодируемый этим геном — регулятор транскрипции. Он содержит в парной амфипатической спирали (PAH) домены, которые важны для белок-белковых взаимодействий и могут опосредовать репрессию при помощи Mad-Max комплекса[3].

Взаимодействия с другими белками

SIN3A как было выявлено, взаимодействует с:

CABIN1[4],
HBP1[5],
HDAC1[6][7][8][9][10][11][12][13][14][15][16][17][18][19],
HDAC9[20][21],
Гистондеацетилаза 2[6][8][9][14][15][22][23],
HCFC1[24][25],
IKZF1[20][26][27],
ING1[19],
KLF11[28][29],
MNT[30],
MXD1[5][31][32],
MBD2[33],
NCOR2[18][34],
OGT[35],
PHF12[36],
Белок промиелоцитарного лейкоза[37],
RBBP4[38][39],
RBBP7[19][39],
SAP130[8],
SAP30[8][13][19][36][39][40],
SMARCA2[41],
SMARCA4[19][41],
SMARCC1[19][41],
SUDS3[8][42],
TAL1[43],
Цинковый палец и BTB домен, содержащий белок 16[44][45][46].

Примечания

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Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast) (неопр.).
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Tong J.K., Hassig C.A., Schnitzler G.R., Kingston R.E., Schreiber S.L. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex (англ.) // Nature : journal. — 1998. — Vol. 395, no. 6705. — P. 917—921. — doi:10.1038/27699. — PMID 9804427.
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Yochum G.S., Ayer D.E. Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex (англ.) // Mol. Cell. Biol. : journal. — 2001. — Vol. 21, no. 13. — P. 4110—4118. — doi:10.1128/MCB.21.13.4110-4118.2001. — PMID 11390640.
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David G., Alland L., Hong S.H., Wong C.W., DePinho R.A., Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein (англ.) // Oncogene : journal. — 1998. — Vol. 16, no. 19. — P. 2549—2556. — doi:10.1038/sj.onc.1202043. — PMID 9627120.
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Литература

Zhang Y., Dufau M.L. Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes. (англ.) // J. Steroid Biochem. Mol. Biol. : journal. — 2003. — Vol. 85, no. 2—5. — P. 401—414. — doi:10.1016/S0960-0760(03)00230-9. — PMID 12943729.
Ayer D.E., Lawrence Q.A., Eisenman R.N. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. (англ.) // Cell : journal. — Cell Press, 1995. — Vol. 80, no. 5. — P. 767—776. — doi:10.1016/0092-8674(95)90355-0. — PMID 7889570.
Hurlin P.J., Quéva C., Koskinen P.J., et al. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. (англ.) // EMBO J. : journal. — 1996. — Vol. 14, no. 22. — P. 5646—5659. — PMID 8521822.
Hassig C.A., Fleischer T.C., Billin A.N., et al. Histone deacetylase activity is required for full transcriptional repression by mSin3A. (англ.) // Cell : journal. — Cell Press, 1997. — Vol. 89, no. 3. — P. 341—347. — doi:10.1016/S0092-8674(00)80214-7. — PMID 9150133.
Laherty C.D., Yang W.M., Sun J.M., et al. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. (англ.) // Cell : journal. — Cell Press, 1997. — Vol. 89, no. 3. — P. 349—356. — doi:10.1016/S0092-8674(00)80215-9. — PMID 9150134.
Zhang Y., Iratni R., Erdjument-Bromage H., et al. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. (англ.) // Cell : journal. — Cell Press, 1997. — Vol. 89, no. 3. — P. 357—364. — doi:10.1016/S0092-8674(00)80216-0. — PMID 9150135.
Meroni G., Reymond A., Alcalay M., et al. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. (англ.) // EMBO J. : journal. — 1997. — Vol. 16, no. 10. — P. 2892—2906. — doi:10.1093/emboj/16.10.2892. — PMID 9184233.
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David G., Alland L., Hong S.H., et al. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. (англ.) // Oncogene : journal. — 1998. — Vol. 16, no. 19. — P. 2549—2556. — doi:10.1038/sj.onc.1202043. — PMID 9627120.
Wong C.W., Privalsky M.L. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. (англ.) // J. Biol. Chem. : journal. — 1998. — Vol. 273, no. 42. — P. 27695—27702. — doi:10.1074/jbc.273.42.27695. — PMID 9765306.
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[3] Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast) (неопр.).

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