HMG20B

Высокомобильная группа 20B
Высокомобильная группа 20B
	; PDB представлено на основе 2crj.
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	2crj
Идентификаторы
Символ	HMG20B ; BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857
Внешние ID	OMIM: 605535 MGI: 1341190 HomoloGene: 74949 GeneCards: HMG20B Gene
Генная онтология
Генная онтология
Функция	• DNA binding; • protein binding; • protein heterodimerization activity;
Компонент клетки	• nucleus; • nucleoplasm; • chromosome; • nucleolus;
Биологический процесс	• transcription, DNA-templated; • regulation of transcription, DNA-templated; • cell cycle; • blood coagulation; • chromatin modification; • negative regulation of protein sumoylation; • skeletal muscle cell differentiation; • positive regulation of neuron differentiation;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

SWI/SNF-связанный, матрично-ассоциированный актинозависимый регулятор хроматина, 1-зависимый член подсемейства E — белок, кодируемый у человека геном HMG20B[1][2].

Взаимодействия

HMG20B, как было выявлено, взаимодействует с KIF4A[3], HDAC1[4], гистондеацетилазой 2[4][5], PHF21A[4][6], RCOR1[4] и BRCA2[4][7].

Примечания

Sumoy L., Carim L., Escarceller M., Nadal M., Gratacos M., Pujana M.A., Estivill X., Peral B. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression (англ.) // Cytogenetics and Genome Research : journal. — 2000. — June (vol. 88, no. 1—2). — P. 62—7. — doi:10.1159/000015486. — PMID 10773667.
Entrez Gene: HMG20B high-mobility group 20B (неопр.).
Lee, Young Mi; Kim Wankee. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 (англ.) // Biochemical Journal : journal. — England, 2003. — September (vol. 374, no. Pt 2). — P. 497—503. — doi:10.1042/BJ20030452. — PMID 12809554.
Hakimi, Mohamed-Ali; Bochar Daniel A; Chenoweth Josh; Lane William S; Mandel Gail; Shiekhattar Ramin. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 2002. — May (vol. 99, no. 11). — P. 7420—7425. — ISSN 0027-8424. — doi:10.1073/pnas.112008599. — PMID 12032298.
Hakimi, Mohamed-Ali; Dong Yuanshu; Lane William S; Speicher David W; Shiekhattar Ramin. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes (англ.) // Journal of Biological Chemistry : journal. — United States, 2003. — February (vol. 278, no. 9). — P. 7234—7239. — ISSN 0021-9258. — doi:10.1074/jbc.M208992200. — PMID 12493763.
Iwase, Shigeki; Januma Aya; Miyamoto Kiyoko; Shono Naomi; Honda Arata; Yanagisawa Junn; Baba Tadashi. Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression (англ.) // Biochemical and Biophysical Research Communications : journal. — United States, 2004. — September (vol. 322, no. 2). — P. 601—608. — ISSN 0006-291X. — doi:10.1016/j.bbrc.2004.07.163. — PMID 15325272.
Marmorstein, L Y; Kinev A V; Chan G K; Bochar D A; Beniya H; Epstein J A; Yen T J; Shiekhattar R. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression (англ.) // Cell : journal. — United States: Cell Press, 2001. — January (vol. 104, no. 2). — P. 247—257. — ISSN 0092-8674. — doi:10.1016/S0092-8674(01)00209-4. — PMID 11207365.

Литература

Wattler F., Wattler S., Kelly M., et al. Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family (англ.) // Genomics : journal. — 1999. — Vol. 60, no. 2. — P. 172—178. — doi:10.1006/geno.1999.5913. — PMID 10486208.
Marmorstein L.Y., Kinev A.V., Chan G.K., et al. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression (англ.) // Cell : journal. — Cell Press, 2001. — Vol. 104, no. 2. — P. 247—257. — doi:10.1016/S0092-8674(01)00209-4. — PMID 11207365.
Lee Y.M., Shin H., Choi W., et al. Characterization of human SMARCE1r high-mobility-group protein (англ.) // Biochimica et Biophysica Acta : journal. — 2002. — Vol. 1574, no. 3. — P. 269—276. — doi:10.1016/s0167-4781(01)00373-6. — PMID 11997092.
Hakimi M.A., Bochar D.A., Chenoweth J., et al. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2002. — Vol. 99, no. 11. — P. 7420—7425. — doi:10.1073/pnas.112008599. — PMID 12032298.
Wang C., McCarty I.M., Balazs L., et al. Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35 (англ.) // Biochemical and Biophysical Research Communications : journal. — 2002. — Vol. 295, no. 1. — P. 129—135. — doi:10.1016/S0006-291X(02)00624-1. — PMID 12083779.
Wang C., McCarty I.M., Balazs L., et al. Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens (англ.) // Biochemical and Biophysical Research Communications : journal. — 2002. — Vol. 295, no. 1. — P. 136—141. — doi:10.1016/S0006-291X(02)00625-3. — PMID 12083780.
Strausberg R.L., Feingold E.A., Grouse L.H., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2003. — Vol. 99, no. 26. — P. 16899—16903. — doi:10.1073/pnas.242603899. — PMID 12477932.
Hakimi M.A., Dong Y., Lane W.S., et al. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes (англ.) // Journal of Biological Chemistry : journal. — 2003. — Vol. 278, no. 9. — P. 7234—7239. — doi:10.1074/jbc.M208992200. — PMID 12493763.
Lee Y.M., Kim W. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 (англ.) // Biochemical Journal : journal. — 2003. — Vol. 374, no. Pt 2. — P. 497—503. — doi:10.1042/BJ20030452. — PMID 12809554.
Ota T., Suzuki Y., Nishikawa T., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs (англ.) // Nature Genetics : journal. — 2004. — Vol. 36, no. 1. — P. 40—5. — doi:10.1038/ng1285. — PMID 14702039.
Grimwood J., Gordon L.A., Olsen A., et al. The DNA sequence and biology of human chromosome 19 (англ.) // Nature : journal. — 2004. — Vol. 428, no. 6982. — P. 529—535. — doi:10.1038/nature02399. — PMID 15057824.
Iwase S., Januma A., Miyamoto K., et al. Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression (англ.) // Biochemical and Biophysical Research Communications : journal. — 2004. — Vol. 322, no. 2. — P. 601—608. — doi:10.1016/j.bbrc.2004.07.163. — PMID 15325272.
Gerhard D.S., Wagner L., Feingold E.A., et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) (англ.) // Genome Research : journal. — 2004. — Vol. 14, no. 10B. — P. 2121—2127. — doi:10.1101/gr.2596504. — PMID 15489334.
Rual J.F., Venkatesan K., Hao T., et al. Towards a proteome-scale map of the human protein-protein interaction network (англ.) // Nature : journal. — 2005. — Vol. 437, no. 7062. — P. 1173—1178. — doi:10.1038/nature04209. — PMID 16189514.

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[pmid10773667-1] Sumoy L., Carim L., Escarceller M., Nadal M., Gratacos M., Pujana M.A., Estivill X., Peral B. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression (англ.) // Cytogenetics and Genome Research : journal. — 2000. — June (vol. 88, no. 1—2). — P. 62—7. — doi:10.1159/000015486. — PMID 10773667.

[entrez-2] Entrez Gene: HMG20B high-mobility group 20B (неопр.).

[pmid12809554-3] Lee, Young Mi; Kim Wankee. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 (англ.) // Biochemical Journal : journal. — England, 2003. — September (vol. 374, no. Pt 2). — P. 497—503. — doi:10.1042/BJ20030452. — PMID 12809554.

[pmid12032298-4] Hakimi, Mohamed-Ali; Bochar Daniel A; Chenoweth Josh; Lane William S; Mandel Gail; Shiekhattar Ramin. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 2002. — May (vol. 99, no. 11). — P. 7420—7425. — ISSN 0027-8424. — doi:10.1073/pnas.112008599. — PMID 12032298.

[pmid12493763-5] Hakimi, Mohamed-Ali; Dong Yuanshu; Lane William S; Speicher David W; Shiekhattar Ramin. A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes (англ.) // Journal of Biological Chemistry : journal. — United States, 2003. — February (vol. 278, no. 9). — P. 7234—7239. — ISSN 0021-9258. — doi:10.1074/jbc.M208992200. — PMID 12493763.

[pmid15325272-6] Iwase, Shigeki; Januma Aya; Miyamoto Kiyoko; Shono Naomi; Honda Arata; Yanagisawa Junn; Baba Tadashi. Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression (англ.) // Biochemical and Biophysical Research Communications : journal. — United States, 2004. — September (vol. 322, no. 2). — P. 601—608. — ISSN 0006-291X. — doi:10.1016/j.bbrc.2004.07.163. — PMID 15325272.

[pmid11207365-7] Marmorstein, L Y; Kinev A V; Chan G K; Bochar D A; Beniya H; Epstein J A; Yen T J; Shiekhattar R. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression (англ.) // Cell : journal. — United States: Cell Press, 2001. — January (vol. 104, no. 2). — P. 247—257. — ISSN 0092-8674. — doi:10.1016/S0092-8674(01)00209-4. — PMID 11207365.