COUP-TFII

Член 2 подсемейства ядерных рецепторов 2 группы F
Член 2 подсемейства ядерных рецепторов 2 группы F
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	3CJW
Идентификаторы
Символ	NR2F2 ; ARP1; CHTD4; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2
Внешние ID	OMIM: 107773 MGI: 1352452 HomoloGene: 7628 IUPHAR: NR2F2 GeneCards: NR2F2 Gene
Генная онтология
Генная онтология
Функция	• retinoic acid binding; • sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • transcription corepressor activity; • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • protein binding; • zinc ion binding; • protein homodimerization activity; • sequence-specific DNA binding;
Компонент клетки	• nucleus;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • neuron migration; • maternal placenta development; • negative regulation of endothelial cell proliferation; • transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter; • lipid metabolic process; • signal transduction; • skeletal muscle tissue development; • fertilization; • anterior/posterior pattern specification; • radial pattern formation; • negative regulation of endothelial cell migration; • intracellular receptor signaling pathway; • forebrain development; • response to estradiol; • steroid hormone mediated signaling pathway; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • blood vessel morphogenesis; • limb development; • placenta blood vessel development; • trophoblast giant cell differentiation; • regulation of transcription involved in lymphatic endothelial cell fate commitment;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

COUP-TFII ( транскрипционный фактор COUP 2 ), известный также как NR2F2 (подсемейство ядерных рецепторов 2, группы F, элемент 2) — белок, кодируемый у человека геном NR2F2[1][2]. Аббревиатура COUP расшифровывается как chicken ovalbumin upstream promoter — расположенный выше по течению промотор овальбумина курицы.

Функция

COUP-TFII играет важную роль в регуляции развития ряда тканей и органов, включая сердце, кровеносные сосуды, мышцы и конечности[3][4].

Глюкокортикоидные рецепторы стимулируют COUP-TFII опосредованную трансактивация генов, а сам COUP-TFII подавляет транскрипционную активность глюкокортикоидных рецепторов[5][6]. COUP-TFII взаимодействует с GATA2, препятствуя дифференцировки адипоцитов[7].

Взаимодействия

COUP-TFII.как было выявлено, взаимодействует с:

Примечания

Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2 (неопр.).
Qiu Y., Krishnan V., Zeng Z., Gilbert D.J., Copeland N.G., Gibson L., Yang-Feng T., Jenkins N.A., Tsai M.J., Tsai S.Y. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes (англ.) // Genomics : journal. — Academic Press, 1995. — September (vol. 29, no. 1). — P. 240—246. — doi:10.1006/geno.1995.1237. — PMID 8530078.
Pereira F.A., Qiu Y., Zhou G., Tsai M.J., Tsai S.Y. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development (англ.) // Genes & Development : journal. — 1999. — April (vol. 13, no. 8). — P. 1037—1049. — doi:10.1101/gad.13.8.1037. — PMID 10215630.
Lee C.T., Li L., Takamoto N., Martin J.F., Demayo F.J., Tsai M.J., Tsai S.Y. The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development (англ.) // Molecular and Cellular Biology : journal. — 2004. — December (vol. 24, no. 24). — P. 10835—10843. — doi:10.1128/MCB.24.24.10835-10843.2004. — PMID 15572686.
De Martino M.U., Bhattachryya N., Alesci S., Ichijo T., Chrousos G.P., Kino T. The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism (англ.) // Molecular Endocrinology : journal. — 2004. — April (vol. 18, no. 4). — P. 820—833. — doi:10.1210/me.2003-0341. — PMID 14739255.
De Martino M.U., Alesci S., Chrousos G.P., Kino T. Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism (англ.) // Annals of the New York Academy of Sciences : journal. — 2004. — June (vol. 1024). — P. 72—85. — doi:10.1196/annals.1321.006. — PMID 15265774.
Xu Z., Yu S., Hsu C.H., Eguchi J., Rosen E.D. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2008. — February (vol. 105, no. 7). — P. 2421—2426. — doi:10.1073/pnas.0707082105. — PMID 18250317.
Smirnov D.A., Hou S., Ricciardi R.P. Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription (англ.) // Virology : journal. — 2000. — March (vol. 268, no. 2). — P. 319—328. — doi:10.1006/viro.1999.0181. — PMID 10704340.
Marcus S.L., Winrow C.J., Capone J.P., Rachubinski R.A. A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor (англ.) // Journal of Biological Chemistry : journal. — 1996. — November (vol. 271, no. 44). — P. 27197—27200. — doi:10.1074/jbc.271.44.27197. — PMID 8910285.
Avram D., Ishmael J.E., Nevrivy D.J., Peterson V.J., Lee S.H., Dowell P., Leid M. Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 (англ.) // Journal of Biological Chemistry : journal. — 1999. — May (vol. 274, no. 20). — P. 14331—14336. — doi:10.1074/jbc.274.20.14331. — PMID 10318855.
Litchfield L.M., Riggs K.A., Hockenberry A.M., Oliver L.D., Barnhart K.G., Cai J., Pierce W.M., Ivanova M.M., Bates P.J., Appana S.N., Datta S., Kulesza P., McBryan J., Young L.S., Klinge C.M. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells (англ.) // PLOS One : journal. — 2012. — May (vol. 7, no. 5). — doi:10.1371/journal.pone.0038278. — PMID 22693611.

Литература

De Martino M.U., Alesci S., Chrousos G.P., Kino T. Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism (англ.) // Annals of the New York Academy of Sciences : journal. — 2004. — Vol. 1024. — P. 72—85. — doi:10.1196/annals.1321.006. — PMID 15265774.
Mietus-Snyder M., Sladek F.M., Ginsburg G.S., Kuo C.F., Ladias J.A., Darnell J.E., Karathanasis S.K. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells (англ.) // Molecular and Cellular Biology : journal. — 1992. — Vol. 12, no. 4. — P. 1708—1718. — PMID 1312668.
Wang L.H., Ing N.H., Tsai S.Y., O'Malley B.W., Tsai M.J. The COUP-TFs compose a family of functionally related transcription factors (англ.) // Gene Expr. : journal. — 1992. — Vol. 1, no. 3. — P. 207—216. — PMID 1820218.
Ladias J.A., Karathanasis S.K. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily (англ.) // Science : journal. — 1991. — Vol. 251, no. 4993. — P. 561—565. — doi:10.1126/science.1899293. — PMID 1899293.
Marcus S.L., Winrow C.J., Capone J.P., Rachubinski R.A. A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor (англ.) // Journal of Biological Chemistry : journal. — 1996. — Vol. 271, no. 44. — P. 27197—27200. — doi:10.1074/jbc.271.44.27197. — PMID 8910285.
Thénot S., Henriquet C., Rochefort H., Cavaillès V. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 (англ.) // Journal of Biological Chemistry : journal. — 1997. — Vol. 272, no. 18. — P. 12062—12068. — doi:10.1074/jbc.272.18.12062. — PMID 9115274.
Chu K., Zingg H.H. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter (англ.) // Journal of Molecular Endocrinology : journal. — 1998. — Vol. 19, no. 2. — P. 163—172. — doi:10.1677/jme.0.0190163. — PMID 9343308.
Bailey P., Sartorelli V., Hamamori Y., Muscat G.E. The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD (англ.) // Nucleic Acids Research : journal. — 1999. — Vol. 26, no. 23. — P. 5501—5510. — doi:10.1093/nar/26.23.5501. — PMID 9826778.
Avram D., Ishmael J.E., Nevrivy D.J., Peterson V.J., Lee S.H., Dowell P., Leid M. Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 (англ.) // Journal of Biological Chemistry : journal. — 1999. — Vol. 274, no. 20. — P. 14331—14336. — doi:10.1074/jbc.274.20.14331. — PMID 10318855.
Smirnov D.A., Hou S., Ricciardi R.P. Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription (англ.) // Virology : journal. — 2000. — Vol. 268, no. 2. — P. 319—328. — doi:10.1006/viro.1999.0181. — PMID 10704340.
Avram D., Fields A., Pretty On Top K., Nevrivy D.J., Ishmael J.E., Leid M. Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors (англ.) // Journal of Biological Chemistry : journal. — 2000. — Vol. 275, no. 14. — P. 10315—10322. — doi:10.1074/jbc.275.14.10315. — PMID 10744719.
Jordan E.M., Worley T., Breen G.A. Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1 (англ.) // Biochemistry : journal. — 2003. — Vol. 42, no. 9. — P. 2656—2663. — doi:10.1021/bi0268347. — PMID 12614160.
Sato Y., Suzuki T., Hidaka K., Sato H., Ito K., Ito S., Sasano H. Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle (англ.) // The Journal of Clinical Endocrinology and Metabolism : journal. — 2003. — Vol. 88, no. 7. — P. 3415—3420. — doi:10.1210/jc.2002-021723. — PMID 12843196.
Colland F., Jacq X., Trouplin V., Mougin C., Groizeleau C., Hamburger A., Meil A., Wojcik J., Legrain P., Gauthier J.M. Functional Proteomics Mapping of a Human Signaling Pathway (англ.) // Genome Research : journal. — 2004. — Vol. 14, no. 7. — P. 1324—1332. — doi:10.1101/gr.2334104. — PMID 15231748.
Kurihara I., Shibata H., Kobayashi S., Suda N., Ikeda Y., Yokota K., Murai A., Saito I., Rainey W.E., Saruta T. Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription (англ.) // Journal of Biological Chemistry : journal. — 2005. — Vol. 280, no. 8. — P. 6721—6730. — doi:10.1074/jbc.M411820200. — PMID 15611122.
Shibata H., Kobayashi S., Kurihara I., Suda N., Yokota K., Murai A., Ikeda Y., Saito I., Rainey W.E., Saruta T. COUP-TF and transcriptional co-regulators in adrenal steroidogenesis (англ.) // Endocrine Research. — Informa Healthcare, 2005. — Vol. 30, no. 4. — P. 795—801. — doi:10.1081/ERC-200044042. — PMID 15666827.

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[entrez-1] Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2 (неопр.).

[pmid8530078-2] Qiu Y., Krishnan V., Zeng Z., Gilbert D.J., Copeland N.G., Gibson L., Yang-Feng T., Jenkins N.A., Tsai M.J., Tsai S.Y. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes (англ.) // Genomics : journal. — Academic Press, 1995. — September (vol. 29, no. 1). — P. 240—246. — doi:10.1006/geno.1995.1237. — PMID 8530078.

[pmid10215630-3] Pereira F.A., Qiu Y., Zhou G., Tsai M.J., Tsai S.Y. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development (англ.) // Genes & Development : journal. — 1999. — April (vol. 13, no. 8). — P. 1037—1049. — doi:10.1101/gad.13.8.1037. — PMID 10215630.

[pmid15572686-4] Lee C.T., Li L., Takamoto N., Martin J.F., Demayo F.J., Tsai M.J., Tsai S.Y. The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development (англ.) // Molecular and Cellular Biology : journal. — 2004. — December (vol. 24, no. 24). — P. 10835—10843. — doi:10.1128/MCB.24.24.10835-10843.2004. — PMID 15572686.

[pmid14739255-5] De Martino M.U., Bhattachryya N., Alesci S., Ichijo T., Chrousos G.P., Kino T. The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism (англ.) // Molecular Endocrinology : journal. — 2004. — April (vol. 18, no. 4). — P. 820—833. — doi:10.1210/me.2003-0341. — PMID 14739255.

[pmid15265774-6] De Martino M.U., Alesci S., Chrousos G.P., Kino T. Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism (англ.) // Annals of the New York Academy of Sciences : journal. — 2004. — June (vol. 1024). — P. 72—85. — doi:10.1196/annals.1321.006. — PMID 15265774.

[pmid18250317-7] Xu Z., Yu S., Hsu C.H., Eguchi J., Rosen E.D. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2008. — February (vol. 105, no. 7). — P. 2421—2426. — doi:10.1073/pnas.0707082105. — PMID 18250317.

[pmid10704340-8] Smirnov D.A., Hou S., Ricciardi R.P. Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription (англ.) // Virology : journal. — 2000. — March (vol. 268, no. 2). — P. 319—328. — doi:10.1006/viro.1999.0181. — PMID 10704340.

[pmid8910285-9] Marcus S.L., Winrow C.J., Capone J.P., Rachubinski R.A. A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor (англ.) // Journal of Biological Chemistry : journal. — 1996. — November (vol. 271, no. 44). — P. 27197—27200. — doi:10.1074/jbc.271.44.27197. — PMID 8910285.

[pmid10318855-10] Avram D., Ishmael J.E., Nevrivy D.J., Peterson V.J., Lee S.H., Dowell P., Leid M. Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 (англ.) // Journal of Biological Chemistry : journal. — 1999. — May (vol. 274, no. 20). — P. 14331—14336. — doi:10.1074/jbc.274.20.14331. — PMID 10318855.

[pmid22693611-11] Litchfield L.M., Riggs K.A., Hockenberry A.M., Oliver L.D., Barnhart K.G., Cai J., Pierce W.M., Ivanova M.M., Bates P.J., Appana S.N., Datta S., Kulesza P., McBryan J., Young L.S., Klinge C.M. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells (англ.) // PLOS One : journal. — 2012. — May (vol. 7, no. 5). — doi:10.1371/journal.pone.0038278. — PMID 22693611.