STAT1

Преобразователь сигнала и активатор транскрипции 1, 91kDa
Преобразователь сигнала и активатор транскрипции 1, 91kDa
	; STAT1 bound to DNA
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1BF5, 1YVL, 2KA6
Идентификаторы
Символ	STAT1 ; CANDF7; ISGF-3; STAT91
Внешние ID	OMIM: 600555 MGI: 103063 HomoloGene: 21428 ChEMBL: 6101 GeneCards: STAT1 Gene
Генная онтология
Генная онтология
Функция	• RNA polymerase II core promoter proximal region sequence-specific DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding; • RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; • double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • signal transducer activity; • tumor necrosis factor receptor binding; • calcium ion binding; • protein binding; • enzyme binding; • CCR5 chemokine receptor binding; • identical protein binding; • protein homodimerization activity;
Компонент клетки	• nuclear chromatin; • nucleus; • nucleoplasm; • nucleolus; • cytoplasm; • cytosol; • axon; • dendrite;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • negative regulation of endothelial cell proliferation; • positive regulation of mesenchymal cell proliferation; • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; • regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • apoptotic process; • JAK-STAT cascade; • response to nutrient; • blood circulation; • response to mechanical stimulus; • viral process; • negative regulation of angiogenesis; • cytokine-mediated signaling pathway; • lipopolysaccharide-mediated signaling pathway; • cellular response to insulin stimulus; • tumor necrosis factor-mediated signaling pathway; • response to cytokine; • negative regulation of macrophage fusion; • cellular response to interferon-beta; • response to drug; • response to hydrogen peroxide; • regulation of apoptotic process; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • response to exogenous dsRNA; • response to peptide hormone; • endothelial cell migration; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of smooth muscle cell proliferation; • response to cAMP; • defense response to virus; • interferon-gamma-mediated signaling pathway; • regulation of interferon-gamma-mediated signaling pathway; • type I interferon signaling pathway; • regulation of type I interferon-mediated signaling pathway; • JAK-STAT cascade involved in growth hormone signaling pathway; • renal tubule development; • metanephric mesenchymal cell proliferation involved in metanephros development; • metanephric mesenchymal cell differentiation; • negative regulation of metanephric nephron tubule epithelial cell differentiation;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

STAT1 является членом семейства транскрипционных факторов преобразователей сигналов и активаторов транскрипции . STAT1 участвует в положительной регуляции генов по сигналам интерферона либо типа I, типа II, или типа III. В ответ на IFN-γ стимуляцию, STAT1 образует гомодимеры или гетеродимеры с STAT3, которые связываются с GAS (Interferon G amma- A ctivated S equence) промоторным элементом; В ответ на любую IFN-α или IFN-β стимуляцию, STAT1 образует гетеродимер с STAT2, который может связываться с ISRE ( I nterferon- S timulated R esponse E lement) промоторным элементом.[1] В любом случае, связывание элемента с промотором приводит к увеличению экспрессии ISG ( I nterferon- S timulated G enes).

Экспрессия STAT1 в том числе может индуцироваться Диаллилдисульфидом , содержащимся в чесноке.[2]

Взаимодействия

STAT1 было показано, взаимодействуют с:

BRCA1,[3]
C-jun,[4]
CD117,[5]
CREB-binding protein,[6]
Calcitriol receptor,[7]
Epidermal growth factor receptor,[8][9]
Fanconi anemia, complementation group C,[10][11][12]
GNB2L1,[13][14]
IFNAR2,[15][13]
IRF1,[16]
ISGF3G[17]
Interleukin 27 receptor, alpha subunit,[18]
MCM5,[19][20]
Mammalian target of rapamycin,[21]
PIAS1,[22]
PRKCD,[21]
PTK2,[23]
Protein kinase R,[24][25]
STAT2,[26][27][28]
STAT3,[29][30][9]
Src,[8][31] and
TRADD.[32]

Примечания

Gale, Michael; Katze M.G., He Y., Gale M. Viruses and interferon: a fight for supremacy (англ.) // Nature Reviews Immunology. — Nature Publishing Group, 2002. — Vol. 2, no. 9. — P. 675—687. — doi:10.1038/nri888. — PMID 12209136.
Lu H.F., Yang J.S., Lin Y.T., Tan T.W., Ip S.W., Li Y.C., Tsou M.F., Chung J.G. Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR (англ.) // Cancer Genomics Proteomics. : journal. — 2007. — Vol. 4, no. 2. — P. 93—7. — PMID 17804871.
Ouchi T., Lee S.W., Ouchi M., Aaronson S.A., Horvath C.M. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — May (vol. 97, no. 10). — P. 5208—5213. — doi:10.1073/pnas.080469697. — PMID 10792030.
Zhang X., Wrzeszczynska M.H., Horvath C.M., Darnell J.E. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation (англ.) // Mol. Cell. Biol. : journal. — 1999. — October (vol. 19, no. 10). — P. 7138—7146. — PMID 10490649.
Deberry C., Mou S., Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor (англ.) // Biochem. J. : journal. — 1997. — October (vol. 327 ( Pt 1)). — P. 73—80. — PMID 9355737.
Zhang J.J., Vinkemeier U., Gu W., Chakravarti D., Horvath C.M., Darnell J.E. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — December (vol. 93, no. 26). — P. 15092—15096. — PMID 8986769.
Vidal M., Ramana C.V., Dusso A.S. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription (англ.) // Mol. Cell. Biol. : journal. — 2002. — April (vol. 22, no. 8). — P. 2777—2787. — PMID 11909970.
Olayioye M.A., Beuvink I., Horsch K., Daly J.M., Hynes N.E. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases (англ.) // J. Biol. Chem. : journal. — 1999. — June (vol. 274, no. 24). — P. 17209—17218. — PMID 10358079.
Xia L., Wang L., Chung A.S., Ivanov S.S., Ling M.Y., Dragoi A.M., Platt A., Gilmer T.M., Fu X.Y., Chin Y.E. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation (англ.) // J. Biol. Chem. : journal. — 2002. — August (vol. 277, no. 34). — P. 30716—30723. — doi:10.1074/jbc.M202823200. — PMID 12070153.
Pang Q., Fagerlie S., Christianson T.A., Keeble W., Faulkner G., Diaz J., Rathbun R.K., Bagby G.C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors (англ.) // Mol. Cell. Biol. : journal. — 2000. — July (vol. 20, no. 13). — P. 4724—4735. — PMID 10848598.
Reuter T.Y., Medhurst A.L., Waisfisz Q., Zhi Y., Herterich S., Hoehn H., Gross H.J., Joenje H., Hoatlin M.E., Mathew C.G., Huber P.A. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport (англ.) // Exp. Cell Res. : journal. — 2003. — October (vol. 289, no. 2). — P. 211—221. — PMID 14499622.
Pang Q., Christianson T.A., Keeble W., Diaz J., Faulkner G.R., Reifsteck C., Olson S., Bagby G.C. The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality (англ.) // Blood : journal. — American Society of Hematology, 2001. — September (vol. 98, no. 5). — P. 1392—1401. — PMID 11520787.
Usacheva A., Smith R., Minshall R., Baida G., Seng S., Croze E., Colamonici O. The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor (англ.) // J. Biol. Chem. : journal. — 2001. — June (vol. 276, no. 25). — P. 22948—22953. — doi:10.1074/jbc.M100087200. — PMID 11301323.
Usacheva A., Tian X., Sandoval R., Salvi D., Levy D., Colamonici O.R. The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex (англ.) // J. Immunol. : journal. — 2003. — September (vol. 171, no. 6). — P. 2989—2994. — PMID 12960323.
Li X., Leung S., Kerr I.M., Stark G.R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling (англ.) // Mol. Cell. Biol. : journal. — 1997. — April (vol. 17, no. 4). — P. 2048—2056. — PMID 9121453.
Chatterjee-Kishore M., van Den Akker F., Stark G.R. Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1 (англ.) // J. Biol. Chem. : journal. — 2000. — July (vol. 275, no. 27). — P. 20406—20411. — doi:10.1074/jbc.M001861200. — PMID 10764778.
Horvath C.M., Stark G.R., Kerr I.M., Darnell J.E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex (англ.) // Mol. Cell. Biol. : journal. — 1996. — December (vol. 16, no. 12). — P. 6957—6964. — PMID 8943351.
Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., Yoshimura A., Yoshida H. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment (англ.) // J. Immunol. : journal. — 2003. — May (vol. 170, no. 10). — P. 4886—4890. — PMID 12734330.
Zhang J.J., Zhao Y., Chait B.T., Lathem W.W., Ritzi M., Knippers R., Darnell J.E. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation (англ.) // EMBO J. : journal. — 1998. — December (vol. 17, no. 23). — P. 6963—6971. — doi:10.1093/emboj/17.23.6963. — PMID 9843502.
DaFonseca C.J., Shu F., Zhang J.J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2001. — March (vol. 98, no. 6). — P. 3034—3039. — doi:10.1073/pnas.061487598. — PMID 11248027.
Kristof A.S., Marks-Konczalik J., Billings E., Moss J. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin (англ.) // J. Biol. Chem. : journal. — 2003. — September (vol. 278, no. 36). — P. 33637—33644. — doi:10.1074/jbc.M301053200. — PMID 12807916.
Liao J., Fu Y., Shuai K. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — May (vol. 97, no. 10). — P. 5267—5272. — PMID 10805787.
Xie B., Zhao J., Kitagawa M., Durbin J., Madri J.A., Guan J.L., Fu X.Y. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion (англ.) // J. Biol. Chem. : journal. — 2001. — June (vol. 276, no. 22). — P. 19512—19523. — doi:10.1074/jbc.M009063200. — PMID 11278462.
Wong A.H., Tam N.W., Yang Y.L., Cuddihy A.R., Li S., Kirchhoff S., Hauser H., Decker T., Koromilas A.E. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways (англ.) // EMBO J. : journal. — 1997. — March (vol. 16, no. 6). — P. 1291—1304. — doi:10.1093/emboj/16.6.1291. — PMID 9135145.
Wong A.H., Durbin J.E., Li S., Dever T.E., Decker T., Koromilas A.E. Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR (англ.) // J. Biol. Chem. : journal. — 2001. — April (vol. 276, no. 17). — P. 13727—13737. — doi:10.1074/jbc.M011240200. — PMID 11278865.
Li X., Leung S., Qureshi S., Darnell J.E., Stark G.R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha (англ.) // J. Biol. Chem. : journal. — 1996. — March (vol. 271, no. 10). — P. 5790—5794. — PMID 8621447.
Dumler I., Kopmann A., Wagner K., Mayboroda O.A., Jerke U., Dietz R., Haller H., Gulba D.C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells (англ.) // J. Biol. Chem. : journal. — 1999. — August (vol. 274, no. 34). — P. 24059—24065. — PMID 10446176.
Fagerlund R., Mélen K., Kinnunen L., Julkunen I. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5 (англ.) // J. Biol. Chem. : journal. — 2002. — August (vol. 277, no. 33). — P. 30072—30078. — doi:10.1074/jbc.M202943200. — PMID 12048190.
Gunaje J.J., Bhat G.J. Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin (англ.) // Biochem. Biophys. Res. Commun. : journal. — 2001. — October (vol. 288, no. 1). — P. 252—257. — doi:10.1006/bbrc.2001.5759. — PMID 11594781.
Spiekermann K., Biethahn S., Wilde S., Hiddemann W., Alves F. Constitutive activation of STAT transcription factors in acute myelogenous leukemia (англ.) // Eur. J. Haematol. : journal. — 2001. — August (vol. 67, no. 2). — P. 63—71. — PMID 11722592.
Cirri P., Chiarugi P., Marra F., Raugei G., Camici G., Manao G., Ramponi G. c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells (англ.) // Biochem. Biophys. Res. Commun. : journal. — 1997. — October (vol. 239, no. 2). — P. 493—497. — doi:10.1006/bbrc.1997.7493. — PMID 9344858.
Wang Y., Wu T.R., Cai S., Welte T., Chin Y.E. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation (англ.) // Mol. Cell. Biol. : journal. — 2000. — July (vol. 20, no. 13). — P. 4505—4512. — PMID 10848577.

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[1] Gale, Michael; Katze M.G., He Y., Gale M. Viruses and interferon: a fight for supremacy (англ.) // Nature Reviews Immunology. — Nature Publishing Group, 2002. — Vol. 2, no. 9. — P. 675—687. — doi:10.1038/nri888. — PMID 12209136.

[2] Lu H.F., Yang J.S., Lin Y.T., Tan T.W., Ip S.W., Li Y.C., Tsou M.F., Chung J.G. Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR (англ.) // Cancer Genomics Proteomics. : journal. — 2007. — Vol. 4, no. 2. — P. 93—7. — PMID 17804871.

[pmid10792030-3] Ouchi T., Lee S.W., Ouchi M., Aaronson S.A., Horvath C.M. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — May (vol. 97, no. 10). — P. 5208—5213. — doi:10.1073/pnas.080469697. — PMID 10792030.

[pmid10490649-4] Zhang X., Wrzeszczynska M.H., Horvath C.M., Darnell J.E. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation (англ.) // Mol. Cell. Biol. : journal. — 1999. — October (vol. 19, no. 10). — P. 7138—7146. — PMID 10490649.

[pmid9355737-5] Deberry C., Mou S., Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor (англ.) // Biochem. J. : journal. — 1997. — October (vol. 327 ( Pt 1)). — P. 73—80. — PMID 9355737.

[pmid8986769-6] Zhang J.J., Vinkemeier U., Gu W., Chakravarti D., Horvath C.M., Darnell J.E. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — December (vol. 93, no. 26). — P. 15092—15096. — PMID 8986769.

[pmid11909970-7] Vidal M., Ramana C.V., Dusso A.S. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription (англ.) // Mol. Cell. Biol. : journal. — 2002. — April (vol. 22, no. 8). — P. 2777—2787. — PMID 11909970.

[pmid10358079-8] Olayioye M.A., Beuvink I., Horsch K., Daly J.M., Hynes N.E. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases (англ.) // J. Biol. Chem. : journal. — 1999. — June (vol. 274, no. 24). — P. 17209—17218. — PMID 10358079.

[pmid12070153-9] Xia L., Wang L., Chung A.S., Ivanov S.S., Ling M.Y., Dragoi A.M., Platt A., Gilmer T.M., Fu X.Y., Chin Y.E. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation (англ.) // J. Biol. Chem. : journal. — 2002. — August (vol. 277, no. 34). — P. 30716—30723. — doi:10.1074/jbc.M202823200. — PMID 12070153.

[pmid10848598-10] Pang Q., Fagerlie S., Christianson T.A., Keeble W., Faulkner G., Diaz J., Rathbun R.K., Bagby G.C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors (англ.) // Mol. Cell. Biol. : journal. — 2000. — July (vol. 20, no. 13). — P. 4724—4735. — PMID 10848598.

[pmid14499622-11] Reuter T.Y., Medhurst A.L., Waisfisz Q., Zhi Y., Herterich S., Hoehn H., Gross H.J., Joenje H., Hoatlin M.E., Mathew C.G., Huber P.A. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport (англ.) // Exp. Cell Res. : journal. — 2003. — October (vol. 289, no. 2). — P. 211—221. — PMID 14499622.

[pmid11520787-12] Pang Q., Christianson T.A., Keeble W., Diaz J., Faulkner G.R., Reifsteck C., Olson S., Bagby G.C. The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality (англ.) // Blood : journal. — American Society of Hematology, 2001. — September (vol. 98, no. 5). — P. 1392—1401. — PMID 11520787.

[pmid11301323-13] Usacheva A., Smith R., Minshall R., Baida G., Seng S., Croze E., Colamonici O. The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor (англ.) // J. Biol. Chem. : journal. — 2001. — June (vol. 276, no. 25). — P. 22948—22953. — doi:10.1074/jbc.M100087200. — PMID 11301323.

[pmid12960323-14] Usacheva A., Tian X., Sandoval R., Salvi D., Levy D., Colamonici O.R. The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex (англ.) // J. Immunol. : journal. — 2003. — September (vol. 171, no. 6). — P. 2989—2994. — PMID 12960323.

[pmid9121453-15] Li X., Leung S., Kerr I.M., Stark G.R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling (англ.) // Mol. Cell. Biol. : journal. — 1997. — April (vol. 17, no. 4). — P. 2048—2056. — PMID 9121453.

[pmid10764778-16] Chatterjee-Kishore M., van Den Akker F., Stark G.R. Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1 (англ.) // J. Biol. Chem. : journal. — 2000. — July (vol. 275, no. 27). — P. 20406—20411. — doi:10.1074/jbc.M001861200. — PMID 10764778.

[pmid8943351-17] Horvath C.M., Stark G.R., Kerr I.M., Darnell J.E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex (англ.) // Mol. Cell. Biol. : journal. — 1996. — December (vol. 16, no. 12). — P. 6957—6964. — PMID 8943351.

[pmid12734330-18] Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., Yoshimura A., Yoshida H. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment (англ.) // J. Immunol. : journal. — 2003. — May (vol. 170, no. 10). — P. 4886—4890. — PMID 12734330.

[pmid9843502-19] Zhang J.J., Zhao Y., Chait B.T., Lathem W.W., Ritzi M., Knippers R., Darnell J.E. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation (англ.) // EMBO J. : journal. — 1998. — December (vol. 17, no. 23). — P. 6963—6971. — doi:10.1093/emboj/17.23.6963. — PMID 9843502.

[pmid11248027-20] DaFonseca C.J., Shu F., Zhang J.J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2001. — March (vol. 98, no. 6). — P. 3034—3039. — doi:10.1073/pnas.061487598. — PMID 11248027.

[pmid12807916-21] Kristof A.S., Marks-Konczalik J., Billings E., Moss J. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin (англ.) // J. Biol. Chem. : journal. — 2003. — September (vol. 278, no. 36). — P. 33637—33644. — doi:10.1074/jbc.M301053200. — PMID 12807916.

[pmid10805787-22] Liao J., Fu Y., Shuai K. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — May (vol. 97, no. 10). — P. 5267—5272. — PMID 10805787.

[pmid11278462-23] Xie B., Zhao J., Kitagawa M., Durbin J., Madri J.A., Guan J.L., Fu X.Y. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion (англ.) // J. Biol. Chem. : journal. — 2001. — June (vol. 276, no. 22). — P. 19512—19523. — doi:10.1074/jbc.M009063200. — PMID 11278462.

[pmid9135145-24] Wong A.H., Tam N.W., Yang Y.L., Cuddihy A.R., Li S., Kirchhoff S., Hauser H., Decker T., Koromilas A.E. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways (англ.) // EMBO J. : journal. — 1997. — March (vol. 16, no. 6). — P. 1291—1304. — doi:10.1093/emboj/16.6.1291. — PMID 9135145.

[pmid11278865-25] Wong A.H., Durbin J.E., Li S., Dever T.E., Decker T., Koromilas A.E. Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR (англ.) // J. Biol. Chem. : journal. — 2001. — April (vol. 276, no. 17). — P. 13727—13737. — doi:10.1074/jbc.M011240200. — PMID 11278865.

[pmid8621447-26] Li X., Leung S., Qureshi S., Darnell J.E., Stark G.R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha (англ.) // J. Biol. Chem. : journal. — 1996. — March (vol. 271, no. 10). — P. 5790—5794. — PMID 8621447.

[pmid10446176-27] Dumler I., Kopmann A., Wagner K., Mayboroda O.A., Jerke U., Dietz R., Haller H., Gulba D.C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells (англ.) // J. Biol. Chem. : journal. — 1999. — August (vol. 274, no. 34). — P. 24059—24065. — PMID 10446176.

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