POLR2K

Полипептид K РНК-полимеразы II (управляемой ДНК), 7.0kDa
Полипептид K РНК-полимеразы II (управляемой ДНК), 7.0kDa
Идентификаторы
Символ	POLR2K ; ABC10-alpha; RPABC4; RPB10alpha; RPB12; RPB7.0; hRPB7.0; hsRPB10a
Внешние ID	OMIM: 606033 MGI: 102725 HomoloGene: 86049 GeneCards: POLR2K Gene
номер EC	2.7.7.6
Генная онтология
Генная онтология
Функция	• RNA polymerase I activity; • RNA polymerase II activity; • RNA polymerase III activity; • DNA binding; • zinc ion binding;
Компонент клетки	• nucleus; • nucleoplasm; • DNA-directed RNA polymerase II, core complex; • DNA-directed RNA polymerase III complex; • DNA-directed RNA polymerase I complex; • cytosol;
Биологический процесс	• mRNA splicing, via spliceosome; • DNA repair; • transcription-coupled nucleotide-excision repair; • nucleotide-excision repair; • regulation of transcription from RNA polymerase I promoter; • transcription from RNA polymerase I promoter; • transcription initiation from RNA polymerase I promoter; • transcription elongation from RNA polymerase I promoter; • termination of RNA polymerase I transcription; • transcription from RNA polymerase II promoter; • transcription initiation from RNA polymerase II promoter; • transcription elongation from RNA polymerase II promoter; • 7-methylguanosine mRNA capping; • transcription from RNA polymerase III promoter; • transcription elongation from RNA polymerase III promoter; • termination of RNA polymerase III transcription; • RNA splicing; • gene expression; • viral process; • positive regulation of type I interferon production; • innate immune response; • positive regulation of viral transcription;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

Субъединица RPABC4 ДНК-зависимых 1РНК-полимераз I, II и III — белок, кодируемый у человека геном POLR2K .

Этот ген кодирует одну из самых маленьких субъединиц РНК-полимеразы II, ответственной за синтез информационной РНК эукариот. Это субъединица является общей для двух других ДНК-зависимых РНК-полимераз[1].

Взаимодействия

POLR2K, как было выявлено, взаимодействует с POLR2C[2].

Примечания

Entrez Gene: POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa (неопр.).
Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M. Interactions between the human RNA polymerase II subunits (англ.) // Journal of Biological Chemistry : journal. — UNITED STATES, 1997. — July (vol. 272, no. 27). — P. 16815—16821. — ISSN 0021-9258. — doi:10.1074/jbc.272.27.16815. — PMID 9201987.

Литература

Jeang K.T. Tat, Tat-associated kinase, and transcription. (англ.) // Journal of Biomedical Science : journal. — 1998. — Vol. 5, no. 1. — P. 24—7. — doi:10.1007/BF02253352. — PMID 9570510.
Yankulov K., Bentley D. Transcriptional control: Tat cofactors and transcriptional elongation. (англ.) // Current Biology : journal. — Cell Press, 1998. — Vol. 8, no. 13. — P. R447—9. — doi:10.1016/S0960-9822(98)70289-1. — PMID 9651670.
Romano G., Kasten M., De Falco G., et al. Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. (англ.) // Journal of Cellular Biochemistry : journal. — 2000. — Vol. 75, no. 3. — P. 357—368. — doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. — PMID 10536359.
Marcello A., Zoppé M., Giacca M. Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. (англ.) // IUBMB Life : journal. — 2002. — Vol. 51, no. 3. — P. 175—181. — doi:10.1080/152165401753544241. — PMID 11547919.
Howe K.J. RNA polymerase II conducts a symphony of pre-mRNA processing activities. (англ.) // Biochimica et Biophysica Acta : journal. — 2002. — Vol. 1577, no. 2. — P. 308—324. — doi:10.1016/s0167-4781(02)00460-8. — PMID 12213660.
Stevens M., De Clercq E., Balzarini J. The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention. (англ.) // Med Res Rev : journal. — 2007. — Vol. 26, no. 5. — P. 595—625. — doi:10.1002/med.20081. — PMID 16838299.
Harrich D., McMillan N., Munoz L., et al. Will diverse Tat interactions lead to novel antiretroviral drug targets? (англ.) // Current drug targets : journal. — 2007. — Vol. 7, no. 12. — P. 1595—1606. — doi:10.2174/138945006779025338. — PMID 17168834.
Jang K.L., Collins M.K., Latchman D.S. The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. (англ.) // Journal of Acquired Immune Deficiency Syndromes : journal. — 1992. — Vol. 5, no. 11. — P. 1142—1147. — PMID 1403646.
Kato H., Sumimoto H., Pognonec P., et al. HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. (англ.) // Genes & Development : journal. — 1992. — Vol. 6, no. 4. — P. 655—666. — doi:10.1101/gad.6.4.655. — PMID 1559613.
Southgate C., Zapp M.L., Green M.R. Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein. (англ.) // Nature : journal. — 1990. — Vol. 345, no. 6276. — P. 640—642. — doi:10.1038/345640a0. — PMID 2190099.
Wu-Baer F., Sigman D., Gaynor R.B. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1995. — Vol. 92, no. 16. — P. 7153—7157. — doi:10.1073/pnas.92.16.7153. — PMID 7638159.
Shpakovski G.V., Acker J., Wintzerith M., et al. Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae (англ.) // Molecular and Cellular Biology : journal. — 1995. — Vol. 15, no. 9. — P. 4702—4710. — PMID 7651387.
Herrmann C.H., Rice A.P. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor (англ.) // Journal of Virology : journal. — 1995. — Vol. 69, no. 3. — P. 1612—1620. — PMID 7853496.
Keen N.J., Gait M.J., Karn J. Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — Vol. 93, no. 6. — P. 2505—2510. — doi:10.1073/pnas.93.6.2505. — PMID 8637904.
Yang X., Herrmann C.H., Rice A.P. The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function (англ.) // Journal of Virology : journal. — 1996. — Vol. 70, no. 7. — P. 4576—4584. — PMID 8676484.
Agostini I., Navarro J.M., Rey F., et al. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB (англ.) // Journal of Molecular Biology : journal. — 1996. — Vol. 261, no. 5. — P. 599—606. — doi:10.1006/jmbi.1996.0485. — PMID 8800208.
Zhou Q., Sharp P.A. Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat (англ.) // Science : journal. — 1996. — Vol. 274, no. 5287. — P. 605—610. — doi:10.1126/science.274.5287.605. — PMID 8849451.
Okamoto H., Sheline C.T., Corden J.L., et al. Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — Vol. 93, no. 21. — P. 11575—11579. — doi:10.1073/pnas.93.21.11575. — PMID 8876177.
Chun R.F., Jeang K.T. Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1 (англ.) // Journal of Biological Chemistry : journal. — 1996. — Vol. 271, no. 44. — P. 27888—27894. — doi:10.1074/jbc.271.44.27888. — PMID 8910388.
Parada C.A., Roeder R.G. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain (англ.) // Nature : journal. — 1996. — Vol. 384, no. 6607. — P. 375—378. — doi:10.1038/384375a0. — PMID 8934526.

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[1] Entrez Gene: POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa (неопр.).

[pmid9201987-2] Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M. Interactions between the human RNA polymerase II subunits (англ.) // Journal of Biological Chemistry : journal. — UNITED STATES, 1997. — July (vol. 272, no. 27). — P. 16815—16821. — ISSN 0021-9258. — doi:10.1074/jbc.272.27.16815. — PMID 9201987.