IRF9

Регуляторный фактор интерферона 9
Регуляторный фактор интерферона 9
Идентификаторы
Символ	IRF9 ; IRF-9; ISGF3; ISGF3G; p48
Внешние ID	OMIM: 147574 MGI: 107587 HomoloGene: 4436 GeneCards: IRF9 Gene
Генная онтология
Генная онтология
Функция	• regulatory region DNA binding; • sequence-specific DNA binding transcription factor activity; • protein binding;
Компонент клетки	• nucleus; • nucleoplasm; • cytoplasm; • cytosol;
Биологический процесс	• regulation of transcription, DNA-templated; • transcription from RNA polymerase II promoter; • cell surface receptor signaling pathway; • cytokine-mediated signaling pathway; • type I interferon biosynthetic process; • defense response to virus; • interferon-gamma-mediated signaling pathway; • type I interferon signaling pathway;
	Источники: Amigo / QuickGO
Ортологи

Регуляторный фактор интерферона 9 — белок, который у человека кодируется геном IRF9, ранее известным под именем ISGF3G[1][2][3]. Кроме того, этот ген был известен под именами p48, ISGF3[3].

Взаимодействия

IRF9, как было выявлено, взаимодействует с белками STAT2[4][5] и STAT1.[4].

Примечания

Veals S.A., Schindler C., Leonard D., Fu X.Y., Aebersold R., Darnell JE Jr, Levy D.E. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins (англ.) // Mol Cell Biol : journal. — 1992. — August (vol. 12, no. 8). — P. 3315—3324. — PMID 1630447.
McCusker D., Wilson M., Trowsdale J. Organization of the genes encoding the human proteasome activators PA28alpha and beta (англ.) // Immunogenetics : journal. — 1999. — June (vol. 49, no. 5). — P. 438—445. — doi:10.1007/s002510050517. — PMID 10199920.
Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa (неопр.).
Horvath, C M; Stark G R; Kerr I M; Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1996. — December (vol. 16, no. 12). — P. 6957—6964. — ISSN 0270-7306. — PMID 8943351.
Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1997. — August (vol. 272, no. 32). — P. 20070—20076. — ISSN 0021-9258. — doi:10.1074/jbc.272.32.20070. — PMID 9242679.

См. также

Интерферон
IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7 и IRF8

Литература

Cebulla C.M., Miller D.M., Sedmak D.D. Viral inhibition of interferon signal transduction (англ.) // Intervirology : journal. — 2000. — Vol. 42, no. 5—6. — P. 325—330. — doi:10.1159/000053968. — PMID 10702714.
Reich N.C. Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation (англ.) // J. Interferon Cytokine Res. : journal. — 2002. — Vol. 22, no. 1. — P. 103—109. — doi:10.1089/107999002753452719. — PMID 11846981.
Robertson N.G., Khetarpal U., Gutiérrez-Espeleta G.A., et al. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening (англ.) // Genomics : journal. — Academic Press, 1995. — Vol. 23, no. 1. — P. 42—50. — doi:10.1006/geno.1994.1457. — PMID 7829101.
David M., Romero G., Zhang Z.Y., et al. In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase (англ.) // J. Biol. Chem. : journal. — 1993. — Vol. 268, no. 9. — P. 6593—6599. — PMID 8454630.
Horvath C.M., Stark G.R., Kerr I.M., Darnell J.E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex (англ.) // Mol. Cell. Biol. : journal. — 1997. — Vol. 16, no. 12. — P. 6957—6964. — PMID 8943351.
Martinez-Moczygemba M., Gutch M.J., French D.L., Reich N.C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 (англ.) // J. Biol. Chem. : journal. — 1997. — Vol. 272, no. 32. — P. 20070—20076. — doi:10.1074/jbc.272.32.20070. — PMID 9242679.
Reddy P.H., Stockburger E., Gillevet P., Tagle D.A. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method (англ.) // Genomics : journal. — Academic Press, 1998. — Vol. 46, no. 2. — P. 174—182. — doi:10.1006/geno.1997.5044. — PMID 9417904.
Lau J.F., Parisien J.P., Horvath C.M. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — Vol. 97, no. 13. — P. 7278—7283. — doi:10.1073/pnas.97.13.7278. — PMID 10860992.
Nehyba J., Hrdlicková R., Burnside J., Bose H.R. A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein (англ.) // Mol. Cell. Biol. : journal. — 2002. — Vol. 22, no. 11. — P. 3942—3957. — doi:10.1128/MCB.22.11.3942-3957.2002. — PMID 11997525.
Chawla-Sarkar M., Leaman D.W., Jacobs B.S., et al. Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1) (англ.) // J. Interferon Cytokine Res. : journal. — 2002. — Vol. 22, no. 5. — P. 603—613. — doi:10.1089/10799900252982089. — PMID 12060499.
Strausberg R.L., Feingold E.A., Grouse L.H., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2003. — Vol. 99, no. 26. — P. 16899—16903. — doi:10.1073/pnas.242603899. — PMID 12477932.
Lau J.F., Nusinzon I., Burakov D., et al. Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription (англ.) // Mol. Cell. Biol. : journal. — 2003. — Vol. 23, no. 2. — P. 620—628. — doi:10.1128/MCB.23.2.620-628.2003. — PMID 12509459.
Jikuya H., Takano J., Kikuno R., et al. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones (англ.) // DNA Res. : journal. — 2003. — Vol. 10, no. 1. — P. 49—57. — doi:10.1093/dnares/10.1.49. — PMID 12693554.
Ota T., Suzuki Y., Nishikawa T., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs (англ.) // Nat. Genet. : journal. — 2004. — Vol. 36, no. 1. — P. 40—5. — doi:10.1038/ng1285. — PMID 14702039.
Thompson H.G., Harris J.W., Lin L., Brody J.P. Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells (англ.) // Exp. Cell Res. : journal. — 2004. — Vol. 295, no. 2. — P. 448—459. — doi:10.1016/j.yexcr.2004.01.019. — PMID 15093743.
Sakamoto S., Potla R., Larner A.C. Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes (англ.) // J. Biol. Chem. : journal. — 2004. — Vol. 279, no. 39. — P. 40362—40367. — doi:10.1074/jbc.M406400200. — PMID 15194680.

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[pmid1630447-1] Veals S.A., Schindler C., Leonard D., Fu X.Y., Aebersold R., Darnell JE Jr, Levy D.E. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins (англ.) // Mol Cell Biol : journal. — 1992. — August (vol. 12, no. 8). — P. 3315—3324. — PMID 1630447.

[pmid10199920-2] McCusker D., Wilson M., Trowsdale J. Organization of the genes encoding the human proteasome activators PA28alpha and beta (англ.) // Immunogenetics : journal. — 1999. — June (vol. 49, no. 5). — P. 438—445. — doi:10.1007/s002510050517. — PMID 10199920.

[entrez-3] Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa (неопр.).

[pmid8943351-4] Horvath, C M; Stark G R; Kerr I M; Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1996. — December (vol. 16, no. 12). — P. 6957—6964. — ISSN 0270-7306. — PMID 8943351.

[pmid9242679-5] Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1997. — August (vol. 272, no. 32). — P. 20070—20076. — ISSN 0021-9258. — doi:10.1074/jbc.272.32.20070. — PMID 9242679.