CDC27

Цикл клеточного деления 27
Цикл клеточного деления 27
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	3T1N
Идентификаторы
Символ	CDC27 ; ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E; H-NUC; HNUC; NUC2
Внешние ID	OMIM: 116946 MGI: 102685 HomoloGene: 960 GeneCards: CDC27 Gene
Генная онтология
Генная онтология
Функция	• protein binding; • protein phosphatase binding;
Компонент клетки	• nucleus; • nucleoplasm; • anaphase-promoting complex; • nucleolus; • cytoplasm; • centrosome; • spindle; • cytosol; • spindle microtubule;
Биологический процесс	• mitotic cell cycle; • metaphase/anaphase transition of mitotic cell cycle; • mitotic spindle assembly checkpoint; • cell proliferation; • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • protein K11-linked ubiquitination;
	Источники: Amigo / QuickGO
Ортологи

Гомолог белка цикла клеточного деления 27 (англ. Cell division cycle protein 27 homolog) — белок, кодируемый у человека геном CDC27[1][2].

Белок, кодируемый этим геном демонстрирует сильное сходство с белком Cdc27 Saccharomyces Cerevisiae (рус. пекарские дрожжи), и генным продуктом Schizosaccharomyces pombe nuc 2. Этот белок является составной частью комплекса стимуляции анафазы (APC), который состоит из восьми белковых субъединиц и высоко консервативен в эукариотических клетках. APC катализирует образование циклин-B-убиквитинного конъюгата, который отвечает за убиквитино-опосредованный протеолиз циклинов B-типа. Этот белок и 3 других членов комплекса APC содержат TPR (тетратрикопептидный повтор), домен белка важный для белок-белкового взаимодействия. У этого белка были выявлены взаимодействия с митотическими белками контрольных точек, включая Mad2, p55CDC и BUBR1, и, таким образом, он может быть вовлечен в управление таймингом митоза[2].

Взаимодействия

CDC27, как было выявлено взаимодействует с ANAPC1[3][4], ANAPC4[3][5], ANAPC5[3][5][6], ANAPC11[3][5], FZR1[7][8], CDC20[3][8][9][10][11][12][13], CDH1[3], CDC23[3][5], PIN1[14][15], CDC16[3][5][12][16], ANAPC7[3][5], MAD2L1[11][12] и ANAPC10[3][5].

Примечания

Tugendreich S., Boguski M.S., Seldin M.S., Hieter P. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1993. — December (vol. 90, no. 21). — P. 10031—10035. — doi:10.1073/pnas.90.21.10031. — PMID 8234252.
Entrez Gene: CDC27 cell division cycle 27 homolog (S. cerevisiae) (неопр.).
Vodermaier, Hartmut C; Gieffers Christian, Maurer-Stroh Sebastian, Eisenhaber Frank, Peters January–Michael. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 (англ.) // Current Biology : journal. — England: Cell Press, 2003. — September (vol. 13, no. 17). — P. 1459—1468. — ISSN 0960-9822. — doi:10.1016/S0960-9822(03)00581-5. — PMID 12956947.
Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M. Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase (англ.) // Journal of Cell Biology : journal. — United States, 2000. — November (vol. 151, no. 4). — P. 749—762. — ISSN 0021-9525. — doi:10.1083/jcb.151.4.749. — PMID 11076961.
Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 2000. — August (vol. 97, no. 16). — P. 8973—8978. — ISSN 0027-8424. — doi:10.1073/pnas.97.16.8973. — PMID 10922056.
Koloteva-Levine, Nadejda; Pinchasi Dalia, Pereman Idan, Zur Amit, Brandeis Michael, Elroy-Stein Orna. The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation (англ.) // Molecular and Cellular Biology : journal. — United States, 2004. — May (vol. 24, no. 9). — P. 3577—3587. — ISSN 0270-7306. — doi:10.1128/MCB.24.9.3577-3587.2004. — PMID 15082755.
Zhou, Yuan; Ching Yick-Pang; Ng Raymond W M; Jin Dong-Yan. Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1 (англ.) // Biochemical Journal : journal. — England, 2003. — September (vol. 374, no. Pt 2). — P. 349—358. — doi:10.1042/BJ20030600. — PMID 12797865.
Kramer, E R; Gieffers C; Hölzl G; Hengstschläger M; Peters J M. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family (англ.) // Current Biology : journal. — ENGLAND: Cell Press, 1998. — November (vol. 8, no. 22). — P. 1207—1210. — ISSN 0960-9822. — doi:10.1016/S0960-9822(07)00510-6. — PMID 9811605.
D'Angiolella, Vincenzo; Mari Cecilia; Nocera Donatella; Rametti Linda; Grieco Domenico. The spindle checkpoint requires cyclin-dependent kinase activity (англ.) // Genes & Development : journal. — United States, 2003. — October (vol. 17, no. 20). — P. 2520—2525. — ISSN 0890-9369. — doi:10.1101/gad.267603. — PMID 14561775.
Kallio, Marko J; Beardmore Victoria A; Weinstein Jasminder; Gorbsky Gary J. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells (англ.) // Journal of Cell Biology : journal. — United States, 2002. — September (vol. 158, no. 5). — P. 841—847. — ISSN 0021-9525. — doi:10.1083/jcb.200201135. — PMID 12196507.
Wassmann, K; Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 1998. — September (vol. 95, no. 19). — P. 11193—11198. — ISSN 0027-8424. — doi:10.1073/pnas.95.19.11193. — PMID 9736712.
Kallio, M; Weinstein J; Daum J R; Burke D J; Gorbsky G J. Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events (англ.) // Journal of Cell Biology : journal. — United States, 1998. — June (vol. 141, no. 6). — P. 1393—1406. — ISSN 0021-9525. — doi:10.1083/jcb.141.6.1393. — PMID 9628895.
Nilsson, Jakob; Yekezare Mona; Minshull Jeremy; Pines Jonathon. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction (англ.) // Nature Cell Biology : journal. — England, 2008. — December (vol. 10, no. 12). — P. 1411—1420. — doi:10.1038/ncb1799. — PMID 18997788.
Shen, M; Stukenberg P T; Kirschner M W; Lu K P. The essential mitotic peptidyl–prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins (англ.) // Genes & Development : journal. — United States, 1998. — March (vol. 12, no. 5). — P. 706—720. — ISSN 0890-9369. — doi:10.1101/gad.12.5.706. — PMID 9499405.
Lu, P J; Zhou X Z; Shen M; Lu K P. Function of WW domains as phosphoserine- or phosphothreonine-binding modules (англ.) // Science : journal. — United States, 1999. — February (vol. 283, no. 5406). — P. 1325—1328. — ISSN 0036-8075. — doi:10.1126/science.283.5406.1325. — PMID 10037602.
Ollendorff, V; Donoghue D J. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex (англ.) // Journal of Biological Chemistry : journal. — United States, 1997. — December (vol. 272, no. 51). — P. 32011—32018. — ISSN 0021-9258. — doi:10.1074/jbc.272.51.32011. — PMID 9405394.

Литература

Tugendreich S., Tomkiel J., Earnshaw W., Hieter P. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition (англ.) // Cell : journal. — Cell Press, 1995. — Vol. 81, no. 2. — P. 261—268. — doi:10.1016/0092-8674(95)90336-4. — PMID 7736578.
Chen P.L., Ueng Y.C., Durfee T. et al. Identification of a human homologue of yeast nuc2 which interacts with the retinoblastoma protein in a specific manner (англ.) // Molecular Cancer Research : journal. — 1995. — Vol. 6, no. 2. — P. 199—210. — PMID 7756179.
Ho P.P., Couch F.J., Brody L.C. et al. Localization of the human homolog of the yeast cell division control 27 gene (CDC27) proximal to ITGB3 on human chromosome 17q21.3 (англ.) // Somatic Cell and Molecular Genetics : journal. — 1996. — Vol. 21, no. 5. — P. 351—355. — doi:10.1007/BF02257470. — PMID 8619132.
Ollendorff V., Donoghue D.J. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex (англ.) // Journal of Biological Chemistry : journal. — 1998. — Vol. 272, no. 51. — P. 32011—32018. — doi:10.1074/jbc.272.51.32011. — PMID 9405394.
Yu H., Peters J.M., King R.W. et al. Identification of a cullin homology region in a subunit of the anaphase-promoting complex (англ.) // Science : journal. — 1998. — Vol. 279, no. 5354. — P. 1219—1222. — doi:10.1126/science.279.5354.1219. — PMID 9469815.
Shen M., Stukenberg P.T., Kirschner M.W., Lu K.P. The essential mitotic peptidyl–prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins (англ.) // Genes & Development : journal. — 1998. — Vol. 12, no. 5. — P. 706—720. — doi:10.1101/gad.12.5.706. — PMID 9499405.
Zhou B.B., Li H., Yuan J., Kirschner M.W. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1998. — Vol. 95, no. 12. — P. 6785—6790. — doi:10.1073/pnas.95.12.6785. — PMID 9618490.
Wassmann K., Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1998. — Vol. 95, no. 19. — P. 11193—11198. — doi:10.1073/pnas.95.19.11193. — PMID 9736712.
Lu P.J., Zhou X.Z., Shen M., Lu K.P. Function of WW domains as phosphoserine- or phosphothreonine-binding modules (англ.) // Science : journal. — 1999. — Vol. 283, no. 5406. — P. 1325—1328. — doi:10.1126/science.283.5406.1325. — PMID 10037602.
Grossberger R., Gieffers C., Zachariae W. et al. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex (англ.) // Journal of Biological Chemistry : journal. — 1999. — Vol. 274, no. 20. — P. 14500—14507. — doi:10.1074/jbc.274.20.14500. — PMID 10318877.
Chan G.K., Jablonski S.A., Sudakin V. et al. Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC (англ.) // Journal of Cell Biology : journal. — 1999. — Vol. 146, no. 5. — P. 941—954. — doi:10.1083/jcb.146.5.941. — PMID 10477750.
Gieffers C., Peters B.H., Kramer E.R. et al. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1999. — Vol. 96, no. 20. — P. 11317—11322. — doi:10.1073/pnas.96.20.11317. — PMID 10500174.
Gmachl M., Gieffers C., Podtelejnikov A.V. et al. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — Vol. 97, no. 16. — P. 8973—8978. — doi:10.1073/pnas.97.16.8973. — PMID 10922056.
Rippmann J.F., Hobbie S., Daiber C. et al. Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis (англ.) // Molecular Cancer Research : journal. — 2000. — Vol. 11, no. 7. — P. 409—416. — PMID 10939594.
Simpson J.C., Wellenreuther R., Poustka A. et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing (англ.) // EMBO Reports : journal. — 2001. — Vol. 1, no. 3. — P. 287—292. — doi:10.1093/embo-reports/kvd058. — PMID 11256614.
Wendt K.S., Vodermaier H.C., Jacob U. et al. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex (англ.) // Nature Structural & Molecular Biology : journal. — 2001. — Vol. 8, no. 9. — P. 784—788. — doi:10.1038/nsb0901-784. — PMID 11524682.
Stroschein S.L., Bonni S., Wrana J.L., Luo K. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN (англ.) // Genes & Development : journal. — 2001. — Vol. 15, no. 21. — P. 2822—2836. — doi:10.1101/gad.912901. — PMID 11691834.
Kallio M.J., Beardmore V.A., Weinstein J., Gorbsky G.J. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells (англ.) // Journal of Cell Biology : journal. — 2002. — Vol. 158, no. 5. — P. 841—847. — doi:10.1083/jcb.200201135. — PMID 12196507.
Topper L.M., Campbell M.S., Tugendreich S. et al. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis (англ.) // Cell Cycle : journal. — 2002. — Vol. 1, no. 4. — P. 282—292. — PMID 12429948.

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[pmid8234252-1] Tugendreich S., Boguski M.S., Seldin M.S., Hieter P. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1993. — December (vol. 90, no. 21). — P. 10031—10035. — doi:10.1073/pnas.90.21.10031. — PMID 8234252.

[entrez-2] Entrez Gene: CDC27 cell division cycle 27 homolog (S. cerevisiae) (неопр.).

[pmid12956947-3] Vodermaier, Hartmut C; Gieffers Christian, Maurer-Stroh Sebastian, Eisenhaber Frank, Peters January–Michael. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 (англ.) // Current Biology : journal. — England: Cell Press, 2003. — September (vol. 13, no. 17). — P. 1459—1468. — ISSN 0960-9822. — doi:10.1016/S0960-9822(03)00581-5. — PMID 12956947.

[pmid11076961-4] Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M. Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase (англ.) // Journal of Cell Biology : journal. — United States, 2000. — November (vol. 151, no. 4). — P. 749—762. — ISSN 0021-9525. — doi:10.1083/jcb.151.4.749. — PMID 11076961.

[pmid10922056-5] Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 2000. — August (vol. 97, no. 16). — P. 8973—8978. — ISSN 0027-8424. — doi:10.1073/pnas.97.16.8973. — PMID 10922056.

[pmid15082755-6] Koloteva-Levine, Nadejda; Pinchasi Dalia, Pereman Idan, Zur Amit, Brandeis Michael, Elroy-Stein Orna. The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation (англ.) // Molecular and Cellular Biology : journal. — United States, 2004. — May (vol. 24, no. 9). — P. 3577—3587. — ISSN 0270-7306. — doi:10.1128/MCB.24.9.3577-3587.2004. — PMID 15082755.

[pmid12797865-7] Zhou, Yuan; Ching Yick-Pang; Ng Raymond W M; Jin Dong-Yan. Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1 (англ.) // Biochemical Journal : journal. — England, 2003. — September (vol. 374, no. Pt 2). — P. 349—358. — doi:10.1042/BJ20030600. — PMID 12797865.

[pmid9811605-8] Kramer, E R; Gieffers C; Hölzl G; Hengstschläger M; Peters J M. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family (англ.) // Current Biology : journal. — ENGLAND: Cell Press, 1998. — November (vol. 8, no. 22). — P. 1207—1210. — ISSN 0960-9822. — doi:10.1016/S0960-9822(07)00510-6. — PMID 9811605.

[pmid14561775-9] D'Angiolella, Vincenzo; Mari Cecilia; Nocera Donatella; Rametti Linda; Grieco Domenico. The spindle checkpoint requires cyclin-dependent kinase activity (англ.) // Genes & Development : journal. — United States, 2003. — October (vol. 17, no. 20). — P. 2520—2525. — ISSN 0890-9369. — doi:10.1101/gad.267603. — PMID 14561775.

[pmid12196507-10] Kallio, Marko J; Beardmore Victoria A; Weinstein Jasminder; Gorbsky Gary J. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells (англ.) // Journal of Cell Biology : journal. — United States, 2002. — September (vol. 158, no. 5). — P. 841—847. — ISSN 0021-9525. — doi:10.1083/jcb.200201135. — PMID 12196507.

[pmid9736712-11] Wassmann, K; Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 1998. — September (vol. 95, no. 19). — P. 11193—11198. — ISSN 0027-8424. — doi:10.1073/pnas.95.19.11193. — PMID 9736712.

[pmid9628895-12] Kallio, M; Weinstein J; Daum J R; Burke D J; Gorbsky G J. Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events (англ.) // Journal of Cell Biology : journal. — United States, 1998. — June (vol. 141, no. 6). — P. 1393—1406. — ISSN 0021-9525. — doi:10.1083/jcb.141.6.1393. — PMID 9628895.

[pmid18997788-13] Nilsson, Jakob; Yekezare Mona; Minshull Jeremy; Pines Jonathon. The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction (англ.) // Nature Cell Biology : journal. — England, 2008. — December (vol. 10, no. 12). — P. 1411—1420. — doi:10.1038/ncb1799. — PMID 18997788.

[pmid9499405-14] Shen, M; Stukenberg P T; Kirschner M W; Lu K P. The essential mitotic peptidyl–prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins (англ.) // Genes & Development : journal. — United States, 1998. — March (vol. 12, no. 5). — P. 706—720. — ISSN 0890-9369. — doi:10.1101/gad.12.5.706. — PMID 9499405.

[pmid10037602-15] Lu, P J; Zhou X Z; Shen M; Lu K P. Function of WW domains as phosphoserine- or phosphothreonine-binding modules (англ.) // Science : journal. — United States, 1999. — February (vol. 283, no. 5406). — P. 1325—1328. — ISSN 0036-8075. — doi:10.1126/science.283.5406.1325. — PMID 10037602.

[pmid9405394-16] Ollendorff, V; Donoghue D J. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex (англ.) // Journal of Biological Chemistry : journal. — United States, 1997. — December (vol. 272, no. 51). — P. 32011—32018. — ISSN 0021-9258. — doi:10.1074/jbc.272.51.32011. — PMID 9405394.