PYCARD

PYCARD
PYCARD
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1UCP, 2KN6, 3J63, 5H8O
Идентификаторы
Символы	PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
Внешние IDs	OMIM: 606838 MGI: 1931465 HomoloGene: 8307 GeneCards: 29108
Генная онтология
Генная онтология
Функции	• гомодимеризация белка; • interleukin-6 receptor binding; • BMP receptor binding; • GO:0001948 связывание с белками плазмы; • связывание похожих белков; • enzyme binding; • cysteine-type endopeptidase activity involved in apoptotic process; • Pyrin domain binding; • cysteine-type endopeptidase activator activity involved in apoptotic process; • myosin I binding; • tropomyosin binding; • protease binding; • transmembrane transporter binding; • protein dimerization activity; • cysteine-type endopeptidase activity;
Компонент клетки	• цитоплазма; • NLRP3 inflammasome complex; • NLRP1 inflammasome complex; • AIM2 inflammasome complex; • Ядрышко; • Эндоплазматический ретикулум; • митохондрия; • IkappaB kinase complex; • клеточное ядро; • secretory granule lumen; • azurophil granule lumen; • внеклеточная область; • цитозоль; • protein-containing complex; • neuronal cell body; • Golgi membrane; • аппарат Гольджи; • мембрана;
Биологический процесс	• positive regulation of cysteine-type endopeptidase activity; • regulation of apoptotic process; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of intrinsic apoptotic signaling pathway; • intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of adaptive immune response; • GO:0051636 defense response to Gram-negative bacterium; • immune system process; • cellular response to tumor necrosis factor; • regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of DNA-binding transcription factor activity; • tumor necrosis factor-mediated signaling pathway; • positive regulation of JNK cascade; • negative regulation of interferon-beta production; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • myeloid dendritic cell activation; • positive regulation of T cell activation; • defense response to virus; • cellular response to interleukin-1; • positive regulation of apoptotic process; • positive regulation of tumor necrosis factor production; • positive regulation of release of cytochrome c from mitochondria; • negative regulation of protein serine/threonine kinase activity; • positive regulation of extrinsic apoptotic signaling pathway; • воспалительная реакция; • cellular response to lipopolysaccharide; • negative regulation of NF-kappaB transcription factor activity; • передача сигнала; • Апоптоз; • Врождённый иммунитет; • neutrophil degranulation; • positive regulation of NF-kappaB transcription factor activity; • activation of innate immune response; • myeloid dendritic cell activation involved in immune response; • positive regulation of antigen processing and presentation of peptide antigen via MHC class II; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of actin filament polymerization; • regulation of protein stability; • positive regulation of interferon-gamma production; • positive regulation of interleukin-6 production; • positive regulation of activated T cell proliferation; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • macropinocytosis; • positive regulation of phagocytosis; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of T cell migration; • positive regulation of defense response to virus by host; • intrinsic apoptotic signaling pathway in response to DNA damage; • response to bacterium; • regulation of autophagy; • interleukin-1 beta production; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • regulation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of inflammatory response; • protein homooligomerization; • activation of cysteine-type endopeptidase activity; • negative regulation of cytokine production involved in inflammatory response; • Протеолиз; • positive regulation of interleukin-1 beta production;
	Источники:Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи
	29108
	66824
	ENSG00000103490
	ENSMUSG00000030793
	Q9ULZ3
	Q9EPB4
	NM_145183; NM_013258; NM_145182
	NM_023258
	NP_037390; NP_660183
	NP_075747
Править (человек)	Править (мышь)

PYCARD, или ASC (сокр. от англ. apoptosis-associated speck-like protein containing a CARD, апоптоз-ассоциированный Speck-подобный белок, содержащий CARD) — цитозольный адаптерный белок. Продукт гена человека PYCARD.[1]

Адаптерный белок включает два домена: N-концевой PYD домен и C-концевой CARD домен. Оба домена входят в большую группу т. н. доменов смерти, состоящих из 6 спиралей, которые опосредуют формирование крупных мультимолекулярных сигнальных комплексов, активирующих каспазу и играющих, таким образом, важную роль в воспалении и апоптозе. В клетках белок ASC находится в цитоплазме, но при активации апоптоза образует сферические белковые агрегаты вблизи клеточного ядра. Существуют две изоформы ASC.[2]

Взаимодействия

PYCARD взаимодействует с белком MEFV.[3]

См. также

Примечания

Entrez Gene: PYCARD PYD and CARD domain containing (неопр.). Дата обращения: 18 сентября 2010.
Entrez Gene: PYCARD PYD and CARD domain containing (неопр.).
Richards, N; Schaner P., Diaz A., Stuckey J., Shelden E., Wadhwa A., Gumucio D L. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis (англ.) // J. Biol. Chem. : journal. — United States, 2001. — October (vol. 276, no. 42). — P. 39320—39329. — ISSN 0021-9258. — doi:10.1074/jbc.M104730200. — PMID 11498534.

Литература

Masumoto J., Taniguchi S., Ayukawa K., et al. ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. (англ.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 48. — P. 33835—33838. — doi:10.1074/jbc.274.48.33835. — PMID 10567338.
Lee S. K., Na S. Y., Jung S. Y., et al. Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2. (англ.) // Mol. Endocrinol. : journal. — 2000. — Vol. 14, no. 6. — P. 915—925. — doi:10.1210/me.14.6.915. — PMID 10847592.
Conway K. E., McConnell B. B., Bowring C. E., et al. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. (англ.) // Cancer Research : journal. — American Association for Cancer Research, 2000. — Vol. 60, no. 22. — P. 6236—6242. — PMID 11103776.
McConnell B. B., Vertino P. M. Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1. (англ.) // Cancer Research : journal. — American Association for Cancer Research, 2000. — Vol. 60, no. 22. — P. 6243—6247. — PMID 11103777.
Martinon F., Hofmann K., Tschopp J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. (англ.) // Curr. Biol. : journal. — 2001. — Vol. 11, no. 4. — P. R118—20. — doi:10.1016/S0960-9822(01)00056-2. — PMID 11250163.
Geddes B. J., Wang L., Huang W. J., et al. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 2001. — Vol. 284, no. 1. — P. 77—82. — doi:10.1006/bbrc.2001.4928. — PMID 11374873.
Richards N., Schaner P., Diaz A., et al. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. (англ.) // J. Biol. Chem. : journal. — 2001. — Vol. 276, no. 42. — P. 39320—39329. — doi:10.1074/jbc.M104730200. — PMID 11498534.
Stimson K. M., Vertino P. M. Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. (англ.) // J. Biol. Chem. : journal. — 2002. — Vol. 277, no. 7. — P. 4951—4958. — doi:10.1074/jbc.M109809200. — PMID 11733524.
Manji G. A., Wang L., Geddes B. J., et al. PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. (англ.) // J. Biol. Chem. : journal. — 2002. — Vol. 277, no. 13. — P. 11570—11575. — doi:10.1074/jbc.M112208200. — PMID 11786556.
Srinivasula S. M., Poyet J. L., Razmara M., et al. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. (англ.) // J. Biol. Chem. : journal. — 2002. — Vol. 277, no. 24. — P. 21119—21122. — doi:10.1074/jbc.C200179200. — PMID 11967258.
Wang L., Manji G. A., Grenier J. M., et al. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (англ.) // J. Biol. Chem. : journal. — 2002. — Vol. 277, no. 33. — P. 29874—29880. — doi:10.1074/jbc.M203915200. — PMID 12019269.
Shiohara M., Taniguchi S., Masumoto J., et al. ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 2002. — Vol. 293, no. 5. — P. 1314—1318. — doi:10.1016/S0006-291X(02)00384-4. — PMID 12054656.
Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. (англ.) // Mol. Cell : journal. — 2002. — Vol. 10, no. 2. — P. 417—426. — doi:10.1016/S1097-2765(02)00599-3. — PMID 12191486.
Strausberg R. L., Feingold E. A., Grouse L. H., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2003. — Vol. 99, no. 26. — P. 16899—16903. — doi:10.1073/pnas.242603899. — PMID 12477932.
Stehlik C., Fiorentino L., Dorfleutner A., et al. The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways. (англ.) // Journal of Experimental Medicine : journal. — Rockefeller University Press, 2003. — Vol. 196, no. 12. — P. 1605—1615. — doi:10.1084/jem.20021552. — PMID 12486103.
Moriai R., Tsuji N., Kobayashi D., et al. A proapoptotic caspase recruitment domain protein gene, TMS1, is hypermethylated in human breast and gastric cancers. (англ.) // Anticancer Res. : journal. — 2003. — Vol. 22, no. 6C. — P. 4163—4168. — PMID 12553049.
Dowds T. A., Masumoto J., Chen F. F., et al. Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 2003. — Vol. 302, no. 3. — P. 575—580. — doi:10.1016/S0006-291X(03)00221-3. — PMID 12615073.
Masumoto J., Dowds T. A., Schaner P., et al. ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 2003. — Vol. 303, no. 1. — P. 69—73. — doi:10.1016/S0006-291X(03)00309-7. — PMID 12646168.
Stehlik C., Krajewska M., Welsh K., et al. The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. (англ.) // Biochem. J. : journal. — 2003. — Vol. 373, no. Pt 1. — P. 101—113. — doi:10.1042/BJ20030304. — PMID 12656673.
Levine J. J., Stimson-Crider K. M., Vertino P. M. Effects of methylation on expression of TMS1/ASC in human breast cancer cells. (англ.) // Oncogene : journal. — 2003. — Vol. 22, no. 22. — P. 3475—3488. — doi:10.1038/sj.onc.1206430. — PMID 12776200.

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[entrez-1] Entrez Gene: PYCARD PYD and CARD domain containing (неопр.). Дата обращения: 18 сентября 2010.

[autogenerated1-2] Entrez Gene: PYCARD PYD and CARD domain containing (неопр.).

[pmid11498534-3] Richards, N; Schaner P., Diaz A., Stuckey J., Shelden E., Wadhwa A., Gumucio D L. Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis (англ.) // J. Biol. Chem. : journal. — United States, 2001. — October (vol. 276, no. 42). — P. 39320—39329. — ISSN 0021-9258. — doi:10.1074/jbc.M104730200. — PMID 11498534.