COPS2

Субъединица 2 сигналосомы COP9
Субъединица 2 сигналосомы COP9
Идентификаторы
Символ	COPS2 ; ALIEN; CSN2; SGN2; TRIP15
Внешние ID	OMIM: 604508 MGI: 1330276 HomoloGene: 134283 GeneCards: COPS2 Gene
Генная онтология
Генная онтология
Функция	• transcription corepressor activity; • signal transducer activity; • protein binding;
Компонент клетки	• cytoplasm; • COP9 signalosome;
Биологический процесс	• negative regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • signal transduction; • cell proliferation; • cullin deneddylation; • neuron differentiation; • skeletal muscle cell differentiation;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
	Больше информации
Ортологи

Субъединица 2 сигналосомного комплекса COP9 — белок, который у человека кодируется геном COPS2.[1][2][3] Он кодирует соответствующую субъединицу сигналосомы COP9 .

Эта статья о белке. О интернет-протоколе см. COPS

Взаимодействия

COPS2, как было выявлено, взаимодействуют с:

DAX1,[4]
IRF8,[5]
NIF3L1,[6] and
THRA.[7]

Примечания

Lee J.W., Choi H.S., Gyuris J., Brent R., Moore D.D. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor (англ.) // Mol Endocrinol : journal. — 1995. — July (vol. 9, no. 2). — P. 243—254. — doi:10.1210/me.9.2.243. — PMID 7776974.
Seeger M., Kraft R., Ferrell K., Bech-Otschir D., Dumdey R., Schade R., Gordon C., Naumann M., Dubiel W. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits (англ.) // The FASEB Journal : journal. — Federation of American Societies for Experimental Biology, 1998. — April (vol. 12, no. 6). — P. 469—478. — PMID 9535219.
Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (неопр.).
Altincicek B., Tenbaum S.P., Dressel U., Thormeyer D., Renkawitz R., Baniahmad A. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita (англ.) // J. Biol. Chem. : journal. — 2000. — March (vol. 275, no. 11). — P. 7662—7667. — PMID 10713076.
Cohen H., Azriel A., Cohen T., Meraro D., Hashmueli S., Bech-Otschir D., Kraft R., Dubiel W., Levi B.Z. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome (англ.) // J. Biol. Chem. : journal. — 2000. — December (vol. 275, no. 50). — P. 39081—39089. — doi:10.1074/jbc.M004900200. — PMID 10991940.
Akiyama H., Fujisawa N., Tashiro Y., Takanabe N., Sugiyama A., Tashiro F. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2 (англ.) // J. Biol. Chem. : journal. — 2003. — March (vol. 278, no. 12). — P. 10752—10762. — doi:10.1074/jbc.M209856200. — PMID 12522100.
Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S.P., Renkawitz R., Baniahmad A. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily (англ.) // Mol. Cell. Biol. : journal. — 1999. — May (vol. 19, no. 5). — P. 3383—3394. — PMID 10207062.

Литература

Wolf D.A., Zhou C., Wee S. The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? (англ.) // Nat. Cell Biol. : journal. — 2004. — Vol. 5, no. 12. — P. 1029—1033. — doi:10.1038/ncb1203-1029. — PMID 14647295.
Maruyama K., Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (англ.) // Gene : journal. — Elsevier, 1994. — Vol. 138, no. 1—2. — P. 171—174. — doi:10.1016/0378-1119(94)90802-8. — PMID 8125298.
Suzuki Y., Yoshitomo-Nakagawa K., Maruyama K., Suyama A., Sugano S. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library (англ.) // Gene : journal. — Elsevier, 1997. — Vol. 200, no. 1—2. — P. 149—156. — doi:10.1016/S0378-1119(97)00411-3. — PMID 9373149.
Wei N., Tsuge T., Serino G., Dohmae N., Takio K., Matsui M., Deng X.W. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex (англ.) // Curr. Biol. : journal. — 1998. — Vol. 8, no. 16. — P. 919—922. — doi:10.1016/S0960-9822(07)00372-7. — PMID 9707402.
Schaefer L., Beermann M.L., Miller J.B. Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien (англ.) // Genomics : journal. — Academic Press, 1999. — Vol. 56, no. 3. — P. 310—316. — doi:10.1006/geno.1998.5728. — PMID 10087198.
Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S.P., Renkawitz R., Baniahmad A. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily (англ.) // Mol. Cell. Biol. : journal. — 1999. — Vol. 19, no. 5. — P. 3383—3394. — PMID 10207062.
Naumann M., Bech-Otschir D., Huang X., Ferrell K., Dubiel W. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK (англ.) // J. Biol. Chem. : journal. — 2000. — Vol. 274, no. 50. — P. 35297—35300. — doi:10.1074/jbc.274.50.35297. — PMID 10585392.
Altincicek B., Tenbaum S.P., Dressel U., Thormeyer D., Renkawitz R., Baniahmad A. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita (англ.) // J. Biol. Chem. : journal. — 2000. — Vol. 275, no. 11. — P. 7662—7667. — doi:10.1074/jbc.275.11.7662. — PMID 10713076.
Hu R.M., Han Z.G., Song H.D., Peng Y.D., Huang Q.H., Ren S.X., Gu Y.J., Huang C.H., Li Y.B., Jiang C.L., Fu G., Zhang Q.H., Gu B.W., Dai M., Mao Y.F., Gao G.F., Rong R., Ye M., Zhou J., Xu S.H., Gu J., Shi J.X., Jin W.R., Zhang C.K., Wu T.M., Huang G.Y., Chen Z., Chen M.D., Chen J.L. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — Vol. 97, no. 17. — P. 9543—9548. — doi:10.1073/pnas.160270997. — PMID 10931946.
Cohen H., Azriel A., Cohen T., Meraro D., Hashmueli S., Bech-Otschir D., Kraft R., Dubiel W., Levi B.Z. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome (англ.) // J. Biol. Chem. : journal. — 2001. — Vol. 275, no. 50. — P. 39081—39089. — doi:10.1074/jbc.M004900200. — PMID 10991940.
Tsuge T., Matsui M., Wei N. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain (англ.) // J. Mol. Biol. : journal. — 2001. — Vol. 305, no. 1. — P. 1—9. — doi:10.1006/jmbi.2000.4288. — PMID 11114242.
Bech-Otschir D., Kraft R., Huang X., Henklein P., Kapelari B., Pollmann C., Dubiel W. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system (англ.) // EMBO J. : journal. — 2001. — Vol. 20, no. 7. — P. 1630—1639. — doi:10.1093/emboj/20.7.1630. — PMID 11285227.
Lyapina S., Cope G., Shevchenko A., Serino G., Tsuge T., Zhou C., Wolf D.A., Wei N., Shevchenko A., Deshaies R.J. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome (англ.) // Science : journal. — 2001. — Vol. 292, no. 5520. — P. 1382—1385. — doi:10.1126/science.1059780. — PMID 11337588.
Hoareau Alves K., Bochard V., Réty S., Jalinot P. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome (англ.) // FEBS Lett. : journal. — 2002. — Vol. 527, no. 1—3. — P. 15—21. — doi:10.1016/S0014-5793(02)03147-2. — PMID 12220626.
Akiyama H., Fujisawa N., Tashiro Y., Takanabe N., Sugiyama A., Tashiro F. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2 (англ.) // J. Biol. Chem. : journal. — 2003. — Vol. 278, no. 12. — P. 10752—10762. — doi:10.1074/jbc.M209856200. — PMID 12522100.
Serino G., Su H., Peng Z., Tsuge T., Wei N., Gu H., Deng X.W. Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex (англ.) // Plant Cell : journal. — 2003. — Vol. 15, no. 3. — P. 719—731. — doi:10.1105/tpc.009092. — PMID 12615944.
Uhle S., Medalia O., Waldron R., Dumdey R., Henklein P., Bech-Otschir D., Huang X., Berse M., Sperling J., Schade R., Dubiel W. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome (англ.) // EMBO J. : journal. — 2003. — Vol. 22, no. 6. — P. 1302—1312. — doi:10.1093/emboj/cdg127. — PMID 12628923.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid7776974-1] Lee J.W., Choi H.S., Gyuris J., Brent R., Moore D.D. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor (англ.) // Mol Endocrinol : journal. — 1995. — July (vol. 9, no. 2). — P. 243—254. — doi:10.1210/me.9.2.243. — PMID 7776974.

[pmid9535219-2] Seeger M., Kraft R., Ferrell K., Bech-Otschir D., Dumdey R., Schade R., Gordon C., Naumann M., Dubiel W. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits (англ.) // The FASEB Journal : journal. — Federation of American Societies for Experimental Biology, 1998. — April (vol. 12, no. 6). — P. 469—478. — PMID 9535219.

[entrez-3] Entrez Gene: COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (неопр.).

[pmid10713076-4] Altincicek B., Tenbaum S.P., Dressel U., Thormeyer D., Renkawitz R., Baniahmad A. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita (англ.) // J. Biol. Chem. : journal. — 2000. — March (vol. 275, no. 11). — P. 7662—7667. — PMID 10713076.

[pmid10991940-5] Cohen H., Azriel A., Cohen T., Meraro D., Hashmueli S., Bech-Otschir D., Kraft R., Dubiel W., Levi B.Z. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome (англ.) // J. Biol. Chem. : journal. — 2000. — December (vol. 275, no. 50). — P. 39081—39089. — doi:10.1074/jbc.M004900200. — PMID 10991940.

[pmid12522100-6] Akiyama H., Fujisawa N., Tashiro Y., Takanabe N., Sugiyama A., Tashiro F. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2 (англ.) // J. Biol. Chem. : journal. — 2003. — March (vol. 278, no. 12). — P. 10752—10762. — doi:10.1074/jbc.M209856200. — PMID 12522100.

[pmid10207062-7] Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S.P., Renkawitz R., Baniahmad A. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily (англ.) // Mol. Cell. Biol. : journal. — 1999. — May (vol. 19, no. 5). — P. 3383—3394. — PMID 10207062.