Rac1

Rac1
Rac1
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0
Идентификаторы
Символы	RAC1, MIG5, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Rac family small GTPase 1, MRD48
Внешние IDs	OMIM: 602048 MGI: 97845 HomoloGene: 69035 GeneCards: 5879
Генная онтология
Генная онтология
Функции	• histone deacetylase binding; • Rho GDP-dissociation inhibitor binding; • GTP-dependent protein binding; • GO:0006184 GTPase activity; • enzyme binding; • GO:0001948 связывание с белками плазмы; • thioesterase binding; • protein kinase binding; • нуклеотид-связывающий; • GTP binding; • protein serine/threonine kinase activity; • GO:0032403 protein-containing complex binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • ATPase binding;
Компонент клетки	• цитоплазма; • цитозоль; • мембрана; • Фокальные контакты; • меланосома; • ruffle membrane; • trans-Golgi network; • клеточное ядро; • cell projection; • extrinsic component of plasma membrane; • экзосома; • lamellipodium; • early endosome membrane; • клеточная мембрана; • Микрофиламенты; • cytoplasmic ribonucleoprotein granule; • endoplasmic reticulum membrane; • Golgi membrane; • phagocytic cup; • GO:0016023 cytoplasmic vesicle; • GO:0005578 внеклеточный матрикс; • secretory granule membrane; • Дендритный шипик; • recycling endosome membrane; • postsynapse; • glutamatergic synapse; • ficolin-1-rich granule membrane;
Биологический процесс	• positive regulation of Rho protein signal transduction; • regulation of respiratory burst; • movement of cell or subcellular component; • non-canonical Wnt signaling pathway; • positive regulation of protein phosphorylation; • positive regulation of actin filament polymerization; • regulation of neuron maturation; • negative regulation of receptor-mediated endocytosis; • platelet activation; • Fc-epsilon receptor signaling pathway; • cellular response to mechanical stimulus; • phagocytosis, engulfment; • vascular endothelial growth factor receptor signaling pathway; • substrate adhesion-dependent cell spreading; • пролиферация; • ruffle assembly; • lamellipodium assembly; • dopaminergic neuron differentiation; • cell-cell junction organization; • Fc-gamma receptor signaling pathway involved in phagocytosis; • ruffle organization; • actin filament organization; • cell motility; • морфогенез анатомической структуры; • Костная резорбция; • response to wounding; • protein localization to plasma membrane; • воспалительная реакция; • regulation of small GTPase mediated signal transduction; • positive regulation of cell-substrate adhesion; • G protein-coupled receptor signaling pathway; • neuron projection morphogenesis; • epithelial cell morphogenesis; • dendrite morphogenesis; • regulation of hydrogen peroxide metabolic process; • engulfment of apoptotic cell; • dendrite development; • auditory receptor cell morphogenesis; • hyperosmotic response; • cerebral cortex GABAergic interneuron development; • хемотаксис; • positive regulation of DNA replication; • actin filament polymerization; • Агрегация клеток; • negative regulation of interleukin-23 production; • homeostasis of number of cells within a tissue; • cell-matrix adhesion; • localization within membrane; • actin cytoskeleton organization; • regulation of cell size; • anatomical structure arrangement; • GO:0007243 intracellular signal transduction; • regulation of cell migration; • Эндоцитоз; • ephrin receptor signaling pathway; • T cell costimulation; • Свёртывание крови; • regulation of defense response to virus by virus; • synaptic transmission, GABAergic; • mast cell chemotaxis; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of substrate adhesion-dependent cell spreading; • embryonic olfactory bulb interneuron precursor migration; • cytoskeleton organization; • cochlea morphogenesis; • positive regulation of neutrophil chemotaxis; • positive regulation of apoptotic process; • regulation of cell morphogenesis; • positive regulation of focal adhesion assembly; • regulation of fibroblast migration; • positive regulation of lamellipodium assembly; • cerebral cortex radially oriented cell migration; • миграция клеток; • semaphorin-plexin signaling pathway; • positive regulation of stress fiber assembly; • Аксональное наведение; • small GTPase mediated signal transduction; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • Wnt signaling pathway, planar cell polarity pathway; • midbrain dopaminergic neuron differentiation; • neuron migration; • фосфорилация белка; • Rho protein signal transduction; • regulation of lamellipodium assembly; • Rac protein signal transduction; • cell projection assembly; • positive regulation of microtubule polymerization; • neutrophil degranulation; • regulation of nitric oxide biosynthetic process; • phosphatidylinositol phosphate biosynthetic process; • hepatocyte growth factor receptor signaling pathway; • regulation of stress fiber assembly; • позитивная регуляция сигналов от протеинкиназы В; • motor neuron axon guidance; • regulation of neutrophil migration; • positive regulation of insulin secretion involved in cellular response to glucose stimulus;
	Источники:Amigo / QuickGO
Профиль экспрессии РНК
	; ;
	Больше информации
Ортологи
	5879
	19353
	ENSG00000136238
	ENSMUSG00000001847
	P63000
	P63001
	NM_198829; NM_006908; NM_018890
	NM_009007; NM_001347530
	NP_008839; NP_061485
	NP_001334459; NP_033033
Править (человек)	Править (мышь)

Rac1 (англ. Ras-related C3 botulinum toxin substrate 1) — внутриклеточный белок из суперсемейства ГТФаз, относится к «малым» G-белкам. Находится в двух состояниях: активном ГТФ-связанном и неактивном ГДФ-связанном состоянии. В своей активной форме Rac1 связывается в клетке с целым рядом эффекторных белков и приводит к регулировке многих клеточных процессов, таких как секреция, фагоцитоз апоптозных клеток, поляризация эпителиальных клеток и индуцированное факторами роста образование мембранных складок и выростов (англ. membrane ruffles).

См. также

Rac2

Библиография

Beckers C.M., van Hinsbergh V.W., van Nieuw Amerongen G.P. Driving Rho GTPase activity in endothelial cells regulates barrier integrity (англ.) // Thromb. Haemost. : journal. — 2010. — January (vol. 103, no. 1). — P. 40—55. — doi:10.1160/TH09-06-0403. — PMID 20062930.
Sawada N., Li Y., Liao J.K. Novel aspects of the roles of Rac1 GTPase in the cardiovascular system (англ.) // Curr Opin Pharmacol : journal. — 2010. — January. — doi:10.1016/j.coph.2009.11.004. — PMID 20060361.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.