Эндотелиальная синтаза оксида азота

Nitric oxide synthase 3 (endothelial cell)
Nitric oxide synthase 3 (endothelial cell)
	; Rendering of 1M9J
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1M9J, 1M9K, 1M9M, 1M9Q, 1M9R, 1NIW, 2LL7, 2MG5, 3EAH, 3NOS, 4D1O, 4D1P
Идентификаторы
Символ	NOS3 ; ECNOS; eNOS
Внешние ID	OMIM: 163729 MGI: 97362 HomoloGene: 504 ChEMBL: 4803 GeneCards: NOS3 Gene
номер EC	1.14.13.39
Генная онтология
Генная онтология
Функция	• actin monomer binding; • NADPH-hemoprotein reductase activity; • nitric-oxide synthase activity; • iron ion binding; • protein binding; • calmodulin binding; • FMN binding; • heme binding; • tetrahydrobiopterin binding; • arginine binding; • cadmium ion binding; • flavin adenine dinucleotide binding; • NADP binding; • scaffold protein binding;
Компонент клетки	• Golgi membrane; • nucleus; • cytoplasm; • cytosol; • cytoskeleton; • plasma membrane; • caveola; • endocytic vesicle membrane;
Биологический процесс	• angiogenesis; • ovulation from ovarian follicle; • in utero embryonic development; • blood vessel remodeling; • regulation of sodium ion transport; • regulation of the force of heart contraction by chemical signal; • regulation of systemic arterial blood pressure by endothelin; • arginine catabolic process; • nitric oxide biosynthetic process; • mitochondrion organization; • nitric oxide mediated signal transduction; • blood coagulation; • regulation of blood pressure; • negative regulation of cell proliferation; • response to heat; • negative regulation of platelet activation; • negative regulation of muscle hyperplasia; • smooth muscle hyperplasia; • removal of superoxide radicals; • lung development; • positive regulation of guanylate cyclase activity; • lipopolysaccharide-mediated signaling pathway; • response to fluid shear stress; • negative regulation of potassium ion transport; • endothelial cell migration; • small molecule metabolic process; • positive regulation of angiogenesis; • negative regulation of blood pressure; • positive regulation of vasodilation; • nitric oxide metabolic process; • vascular endothelial growth factor receptor signaling pathway; • regulation of blood vessel size; • regulation of nitric-oxide synthase activity; • negative regulation of hydrolase activity; • interaction with host; • negative regulation of calcium ion transport; • oxidation-reduction process; • phagosome maturation; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
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Ортологи

Эндотелиальная синтаза оксида азота (eNOS) — одна из NO-синтаз человека, кодируемая геном NOS3 на 7-й хромосоме. Фермент eNOS и ген NOS3 были описаны в 1992-1993 годах.[1][2][3]

Синтезируя NO в кровеносных сосудах, NOS3 влияет на их работу.

Примечания

Janssens, S. P.; Shimouchi, A.; Quertermous, T.; Bloch, D. B.; Bloch, K. D. : Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J. Biol. Chem. 267: 14519-14522, 1992. PMID 1378832
Marsden, P. A.; Schappert, K. T.; Chen, H. S.; Flowers, M.; Sundell, C. L.; Wilcox, J. N.; Lamas, S.; Michel, T. : Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 307: 287-293, 1992. PMID 1379542
Marsden, P. A.; Heng, H. H. Q.; Scherer, S. W.; Stewart, R. J.; Hall, A. V.; Shi, X.-M.; Tsui, L.-C.; Schappert, K. T. : Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J. Biol. Chem. 268: 17478-17488, 1993. PMID 7688726

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[dis1-1] Janssens, S. P.; Shimouchi, A.; Quertermous, T.; Bloch, D. B.; Bloch, K. D. : Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J. Biol. Chem. 267: 14519-14522, 1992. PMID 1378832

[dis2-2] Marsden, P. A.; Schappert, K. T.; Chen, H. S.; Flowers, M.; Sundell, C. L.; Wilcox, J. N.; Lamas, S.; Michel, T. : Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 307: 287-293, 1992. PMID 1379542

[dis3-3] Marsden, P. A.; Heng, H. H. Q.; Scherer, S. W.; Stewart, R. J.; Hall, A. V.; Shi, X.-M.; Tsui, L.-C.; Schappert, K. T. : Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J. Biol. Chem. 268: 17478-17488, 1993. PMID 7688726